单细胞多组学揭示 ENL 突变通过重新调整基因调控景观扰乱肾脏发育轨迹。
Mesh : Animals Mice Single-Cell Analysis Kidney / metabolism pathology Mutation Cell Differentiation / genetics Gene Expression Regulation, Developmental Chromatin / metabolism Epigenesis, Genetic Wilms Tumor / genetics pathology metabolism Histones / metabolism Acetylation Humans Organogenesis / genetics Wnt Signaling Pathway / genetics Nephrons / metabolism pathology embryology Transcriptome / genetics Transcription Factors / genetics metabolism Female Male Multiomics
来 源:
DOI:10.1038/s41467-024-50171-w
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