Abstract：
The agropastoral farmers have employed Turraea vogelii(TVL),Senna podocarpa(SPL), and Jaundea pinnata (JPL) leaves for treating various diseases, including intestinal parasites in livestock and the human population in Nigeria. Gastrointestinal nematodes are highly significant to livestock production and people\'s health, and natural products are interesting as sources of new drugs. In this study, we evaluated the effectiveness of extracts derived from these plants in treating parasitic infections using third-stage infective larvae (L3) of Strongyloides venezuelensis. We obtained crude extracts using n-gexane (Hex), ethyl acetate (Ea), and methanol (Met). The extracts were analyzed for their phytochemical composition, and their ability to prevent hemolysis were tested. The mean concentrations of total phenols in SPL Hex, SPL Ea, and SPL Met were 92.3 ± 0.3, 103.0 ± 0.4, and 128.2 ± 0.5 mg/100 g, respectively. Total tannin concentrations for JPL Ea, SPL Ea, SPL Hex, and TVL Hex were 60.3 ± 0.1, 89.2 ± 0.2, 80.0 ± 0.1, and 66.6 ± 0.3 mg/100 g, respectively. The mean lethal concentration (LC50) at 72 h for JPL Ea 39 (26-61) μg/mL. SPL Ea was 39 (34-45) μg/mL, and TVL Hex 31 (26-36) μg/mL. The antiparasitic activities of the extracts against L3 were dose- and time-dependent. All the extracts were slightly hemolytic to the erythrocytes. In this study, the plant extract tested demonstrated significant anti-S. venezuelensis activity. These phytobotanical extracts could be used to create formulations for the potential treatment of helminthiasis in animals and humans.
摘要：
农牧农民雇用了Turraeavogelii（TVL），SennaPodocarpa（SPL），和Jaundeapinnata（JPL）叶用于治疗各种疾病，包括尼日利亚牲畜和人口中的肠道寄生虫。胃肠道线虫对畜牧业生产和人们的健康具有重要意义,和天然产品作为新药的来源很有趣。在这项研究中,我们评估了从这些植物中提取的提取物在使用委内瑞拉类线虫的第三阶段感染幼虫（L3）治疗寄生虫感染中的有效性。我们使用n-gexane（Hex）获得了粗提取物，乙酸乙酯(Ea),和甲醇（Met）。分析了提取物的植物化学成分，并对其防止溶血的能力进行了测试。SPLHex中总酚的平均浓度，SPLEa,和SPLMet分别为92.3±0.3、103.0±0.4和128.2±0.5mg/100g，分别。JPLEa的总单宁浓度，SPLEa,SPL十六进制,TVLHex分别为60.3±0.1、89.2±0.2、80.0±0.1和66.6±0.3mg/100g，分别。JPLEa39（26-61）μg/mL在72小时的平均致死浓度（LC50）。SPLEa为39（34-45）μg/mL，和TVLHex31(26-36)μg/mL。提取物对L3的抗寄生虫活性是剂量和时间依赖性的。所有提取物对红细胞有轻微溶血作用。在这项研究中,测试的植物提取物显示出显著的抗S。委内瑞拉活动。这些植物植物提取物可用于制造用于动物和人类蠕虫病的潜在治疗的制剂。
