Abstract：
This study reviews global levels of ochratoxin A (OTA) in infant formula and cereal-based foods, using Monte Carlo simulation to assess risks. The review found 24 studies on global OTA levels in infant food and cereal-based products, using databases including PubMed, Scopus, Web of Science and Embase until March 2024. We estimated OTA exposure in infant food based on concentration, intake and body weight. The exposure and hazard quotient margin were calculated using BMDL10 and TDI values. Monte Carlo simulation evaluated human health risks from OTA in infant formula and cereal-based foods. A global study from 14 countries shows varying levels, surpassing EU limits in Tunisia, Ecuador, the USA, and generally in Africa, notably in infant cereals, which had higher levels than formula. Globally, OTA was present in 29.3% of the 3348 samples analyzed, with Lebanon at 95.2% and Brazil at 0%. Analysis indicates only non-carcinogenic risk for infants. While health risks for infants are mostly low, ongoing research and monitoring are vital to minimize OTA exposure in infant food.
摘要：
这项研究回顾了婴儿配方食品和谷物食品中的OchratoxinA（OTA）的全球水平，使用蒙特卡罗模拟来评估风险。该评论发现了24项关于婴儿食品和谷物产品中全球OTA水平的研究，使用包括PubMed在内的数据库，Scopus,WebofScience和Embase至2024年3月。我们根据浓度估计了婴儿食品中的OTA暴露，摄入量和体重。使用BMDL10和TDI值计算暴露量和危险商裕度。蒙特卡罗模拟评估了OTA在婴儿配方食品和谷物食品中的人类健康风险。来自14个国家的一项全球研究显示了不同的水平，超越欧盟在突尼斯的限制，厄瓜多尔,美国,一般来说，在非洲，特别是在婴儿谷物中，比配方更高的水平。全球范围内,在分析的3348个样品中，有29.3％存在OTA，黎巴嫩占95.2%，巴西占0%。分析表明婴儿只有非致癌风险。虽然婴儿的健康风险大多很低，持续的研究和监测对于减少婴儿食品中的OTA暴露至关重要。
