Abstract：
The medial prefrontal cortex (mPFC) plays a critical role in recalling recent and remote fearful memories. Modern neuroscience techniques, such as projection-specific circuit manipulation and activity-dependent labeling, have illuminated how mPFC memory ensembles are reorganized over time. This chapter discusses the implications of new findings for traditional theories of memory, such as the systems consolidation theory and theories of memory engrams. It also examines the specific contributions of mPFC subregions, like the prelimbic and infralimbic cortices, in fear memory, highlighting how their distinct connections influence memory recall. Further, it elaborates on the cellular and molecular changes within the mPFC that support memory persistence and how these are influenced by interactions with the hippocampus. Ultimately, this chapter provides insights into how lasting memories are dynamically encoded in prefrontal circuits, arguing for a key role of memory ensembles that extend beyond strict definitions of the engram.
摘要：
内侧前额叶皮层（mPFC）在回忆最近和远程恐惧记忆中起着至关重要的作用。现代神经科学技术,例如特定于投影的电路操作和依赖于活动的标记，已经阐明了mPFC内存集合体是如何随着时间的推移而重组的。本章讨论了新发现对传统记忆理论的影响，如系统整合理论和记忆记忆理论。它还审查了mPFC次区域的具体贡献，像前边缘和外边缘皮层，在恐惧记忆中，强调他们不同的联系如何影响记忆回忆。Further,它详细阐述了mPFC内支持记忆持久性的细胞和分子变化，以及这些变化如何受到与海马体相互作用的影响。最终,本章提供了有关持久记忆如何在前额叶电路中动态编码的见解，争论一个关键角色的内存集合，延伸到严格的定义范围之外的统一。
