PDF(Pubmed)
Abstract：
UNASSIGNED: This study aims to investigate the potential in vivo relationship between macular pigment (MP) and retinal layers thickness in healthy subjects and dry, non-advanced age-related macular degeneration (AMD).
UNASSIGNED: An observational, cross-sectional study was conducted. Healthy subjects >40 years and patients with early or intermediate AMD were recruited. Structural OCT and macular pigment optical volume (MPOV) were collected for each subject. Retinal layers parameters were calculated based on the standard early treatment diabetic retinopathy study (ETDRS) map. Additionally, MPOV within 1°, 2°, and 9° of eccentricity was assessed and associated with retinal layers thickness and volume. Linear mixed-effects models were used to test the relationship between MP and structural OCT parameters, while adjusting for known possible confounding factors.
UNASSIGNED: A total of 144 eyes of 91 subjects (60.4% females) were evaluated, comprising 43% normal eyes and 57% with early/intermediate AMD. Among the retinal layers, only the outer nuclear layer (ONL) thickness and volume appeared to be associated to higher MP levels. Specifically, the central ONL thickness was identified as a significant predictor of the MPOV 1°(P = 0.04), while the parafoveal ONL thickness (inner ETDRS subfield) was identified as a significant fixed effect on the MPOV 9° (P = 0.037). Age and the presence of drusen or subretinal drusenoid deposits were also tested without showing significant correlations.
UNASSIGNED: Among the retinal layers examined, only the ONL thickness demonstrated a significant association with MPOV. Consequently, ONL thickness might serve as a potential biomarker related to MP levels.
UNASSIGNED: An observational, cross-sectional study was conducted. Healthy subjects >40 years and patients with early or intermediate AMD were recruited. Structural OCT and macular pigment optical volume (MPOV) were collected for each subject. Retinal layers parameters were calculated based on the standard early treatment diabetic retinopathy study (ETDRS) map. Additionally, MPOV within 1°, 2°, and 9° of eccentricity was assessed and associated with retinal layers thickness and volume. Linear mixed-effects models were used to test the relationship between MP and structural OCT parameters, while adjusting for known possible confounding factors.
UNASSIGNED: A total of 144 eyes of 91 subjects (60.4% females) were evaluated, comprising 43% normal eyes and 57% with early/intermediate AMD. Among the retinal layers, only the outer nuclear layer (ONL) thickness and volume appeared to be associated to higher MP levels. Specifically, the central ONL thickness was identified as a significant predictor of the MPOV 1°(P = 0.04), while the parafoveal ONL thickness (inner ETDRS subfield) was identified as a significant fixed effect on the MPOV 9° (P = 0.037). Age and the presence of drusen or subretinal drusenoid deposits were also tested without showing significant correlations.
UNASSIGNED: Among the retinal layers examined, only the ONL thickness demonstrated a significant association with MPOV. Consequently, ONL thickness might serve as a potential biomarker related to MP levels.
摘要：
■本研究旨在研究健康受试者和干燥受试者中黄斑色素（MP）与视网膜层厚度之间的潜在体内关系，非晚期年龄相关性黄斑变性（AMD）。
■观测，进行了横断面研究。招募健康受试者>40岁和患有早期或中期AMD的患者。收集每个受试者的结构OCT和黄斑色素光学体积(MPOV)。基于标准早期治疗糖尿病视网膜病变研究(ETDRS)图计算视网膜层参数。此外,1°内的MPOV,2°,评估了9°的偏心率，并与视网膜层的厚度和体积相关。线性混合效应模型用于测试MP和结构OCT参数之间的关系，同时调整已知可能的混杂因素。
■共评估了91名受试者（60.4%为女性）的144只眼，包括43％的正常眼睛和57％的早期/中期AMD。在视网膜层中，只有外核层(ONL)的厚度和体积似乎与更高的MP水平相关.具体来说,中心ONL厚度被确定为MPOV1°的显著预测因子(P=0.04)，而旁凹ONL厚度（内部ETDRS子场）被确定为对MPOV9°的显着固定影响（P=0.037）。还测试了年龄以及玻璃疣或视网膜下玻璃疣沉积物的存在，而没有显示出明显的相关性。
■在检查的视网膜层中，只有ONL厚度显示与MPOV显著相关。因此,ONL厚度可能作为与MP水平相关的潜在生物标志物。
■观测，进行了横断面研究。招募健康受试者>40岁和患有早期或中期AMD的患者。收集每个受试者的结构OCT和黄斑色素光学体积(MPOV)。基于标准早期治疗糖尿病视网膜病变研究(ETDRS)图计算视网膜层参数。此外,1°内的MPOV,2°,评估了9°的偏心率，并与视网膜层的厚度和体积相关。线性混合效应模型用于测试MP和结构OCT参数之间的关系，同时调整已知可能的混杂因素。
■共评估了91名受试者（60.4%为女性）的144只眼，包括43％的正常眼睛和57％的早期/中期AMD。在视网膜层中，只有外核层(ONL)的厚度和体积似乎与更高的MP水平相关.具体来说,中心ONL厚度被确定为MPOV1°的显著预测因子(P=0.04)，而旁凹ONL厚度（内部ETDRS子场）被确定为对MPOV9°的显着固定影响（P=0.037）。还测试了年龄以及玻璃疣或视网膜下玻璃疣沉积物的存在，而没有显示出明显的相关性。
■在检查的视网膜层中，只有ONL厚度显示与MPOV显著相关。因此,ONL厚度可能作为与MP水平相关的潜在生物标志物。
