Abstract：
The Planning and Acting Network for Low Dose Radiation Research in Japan (PLANET) was established in 2017 in response to the need for an all-Japan network of experts. It serves as an academic platform to propose strategies and facilitate collaboration to improve quantitative estimation of health risks from ionizing radiation at low-doses and low-dose-rates. PLANET established Working Group 1 (Dose-Rate Effects in Animal Experiments) to consolidate findings from animal experiments on dose-rate effects in carcinogenesis. Considering international trends in this field as well as the situation in Japan, PLANET updated its priority research areas for Japanese low-dose radiation research in 2023 to include (i) characterization of low-dose and low-dose-rate radiation risk, (ii) factors to be considered for individualization of radiation risk, (iii) biological mechanisms of low-dose and low-dose-rate radiation effects and (iv) integration of epidemiology and biology. In this context, PLANET established Working Group 2 (Dose and Dose-Rate Mapping for Radiation Risk Studies) to identify the range of doses and dose rates at which observable effects on different endpoints have been reported; Working Group 3 (Species- and Organ-Specific Dose-Rate Effects) to consider the relevance of stem cell dynamics in radiation carcinogenesis of different species and organs; and Working Group 4 (Research Mapping for Radiation-Related Carcinogenesis) to sort out relevant studies, including those on non-mutagenic effects, and to identify priority research areas. These PLANET activities will be used to improve the risk assessment and to contribute to the revision of the next main recommendations of the International Commission on Radiological Protection.
摘要：
日本低剂量辐射研究规划和代理网络（PLANET）成立于2017年，以应对全日本专家网络的需求。它作为一个学术平台，提出战略和促进合作，以改善低剂量和低剂量率电离辐射的健康风险的定量估计。PLANET成立了第1工作组（动物实验中的剂量率效应），以巩固动物实验对致癌作用中剂量率效应的发现。考虑到这一领域的国际趋势以及日本的情况，PLANET在2023年更新了日本低剂量辐射研究的优先研究领域，以包括（i）低剂量和低剂量率辐射风险的表征，(ii)辐射风险个体化应考虑的因素，（iii）低剂量和低剂量率辐射效应的生物学机制，以及（iv）流行病学和生物学的整合。在这种情况下，PLANET成立了第2工作组（辐射风险研究的剂量和剂量率图），以确定已报告的对不同终点的可观察影响的剂量和剂量率范围；第3工作组（物种和器官特定剂量率效应），以考虑干细胞动力学在不同物种和器官的辐射致癌作用中的相关性；第4工作组（辐射相关致癌作用的研究图），以整理相关研究，包括那些非诱变效应，并确定优先研究领域。这些PLANET活动将用于改进风险评估，并有助于修订国际辐射防护委员会的下一个主要建议。
