UNASSIGNED: A total of 126 patients with obesity who completed a 6-month weight loss program were divided into three groups based on weight loss rate (%): low (< 3%), middle (3-10%), and high (≥10%). The International Physical Activity Questionnaire was used for assessing physical activity, whereas dual X-ray absorptiometry was used to determine body composition. Serum MST and FST levels were measured using the enzyme-linked immunosorbent assay.
UNASSIGNED: The middle and high groups showed a significant decrease in percent body fat and a significant increase in percent lean body mass and physical activity. Serum MST levels increased significantly in all three groups, although FST levels reduced significantly only in the middle group. After adjusting for sex and body composition, changes in peak oxygen intake (β = -0.359) and serum FST levels (β = -0.461) were identified as independent factors for the change in MST levels in the low group. Sex (β = -0.420) and changes in MST levels (β = -0.525) were identified as independent factors for the change in serum FST levels in the low group, whereas in the high group, sitting time (β = -0.600) during the weight loss program was identified as an independent factor for change in serum FST levels.
UNASSIGNED: Serum MST levels in patients with obesity increased significantly following the weight loss program, independent of weight loss rate. In contrast, serum FST levels reduced significantly only in the 3-10% weight loss group. These findings indicate that MST and FST secretion dynamics may fluctuate in response to physical activity, while also reflecting feedback regulation of body composition and metabolism during weight reduction.
■根据体重减轻率(%):低(<3%),总共126名完成了6个月减肥计划的肥胖患者分为三组,中等(3-10%),高(≥10%)。国际身体活动问卷用于评估身体活动,而双重X射线吸收法用于确定身体成分。使用酶联免疫吸附测定法测量血清MST和FST水平。
■中高组的体脂百分比显着降低,瘦体重和身体活动百分比显着增加。三组血清MST水平均显著升高,虽然FST水平仅在中间组显著降低。在调整了性别和身体成分后,峰值氧摄入量(β=-0.359)和血清FST水平(β=-0.461)的变化被确定为低组MST水平变化的独立因素。性别(β=-0.420)和MST水平的变化(β=-0.525)被确定为低组血清FST水平变化的独立因素,而在高级群体中,减肥计划期间的坐位时间(β=-0.600)被确定为血清FST水平变化的独立因素。
■减肥计划后,肥胖患者的血清MST水平显着增加,与体重减轻率无关。相比之下,血清FST水平仅在3-10%体重减轻组中显着降低。这些发现表明,MST和FST分泌动力学可能会随着身体活动而波动,同时也反映了减肥过程中身体成分和新陈代谢的反馈调节。