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Abstract：
UNASSIGNED: To investigate the relationship between dry eye disease (DED) and myopia in Japanese teenagers.
UNASSIGNED: This clinic-based, retrospective, cross-sectional study assessed DED condition in 10- to 19-year-old teenagers presenting at Japanese eye clinics. They included 106 high myopic patients (HM; mean age, 16.4 ± 2.2 years), 494 mild myopic patients (15.0 ± 2.6 years) and 82 non-myopic teenagers (NM; 13.8 ± 2.6 years). Subjective refraction and anisometropia were measured. Myopia grade was classified as HM (≤ -6.00 D), MM (> -6.00 D, < -0.50 D), or NM (≥ -0.5 D). The presence of DED-related symptoms including dryness, irritation, pain, fatigue, blurring and photophobia were assessed through a questionnaire. Tear film break-up time (BUT) and fluorescein corneal staining were investigated. Comparison among three groups and regression analysis of myopic error and other variables were conducted.
UNASSIGNED: Anisometropia and astigmatic error were greatest in the HM group compared with the other groups (p < 0.001). The HM group reported less photophobia (p < 0.001) and less pain (p = 0.039) compared with the NM group. Regression analysis revealed that myopic error was correlated with astigmatic error (β = -0.231, p <0.001), anisometropia (β = -0.191, p <0.001), short BUT (β = -0.086, p = 0.028) and the presence of diagnosed DED (β = -0.112, p = 0.003). Dryness (β = -0.127 p = 0.004), photophobia (β = 0.117, p = 0.002) and pain (β = 0.084, p = 0.034) correlated with myopic error.
UNASSIGNED: This study associated clinical findings of DED in HM teenagers. The present results suggest DED might be associated with myopia, possibly in a reciprocal relationship.
UNASSIGNED: This clinic-based, retrospective, cross-sectional study assessed DED condition in 10- to 19-year-old teenagers presenting at Japanese eye clinics. They included 106 high myopic patients (HM; mean age, 16.4 ± 2.2 years), 494 mild myopic patients (15.0 ± 2.6 years) and 82 non-myopic teenagers (NM; 13.8 ± 2.6 years). Subjective refraction and anisometropia were measured. Myopia grade was classified as HM (≤ -6.00 D), MM (> -6.00 D, < -0.50 D), or NM (≥ -0.5 D). The presence of DED-related symptoms including dryness, irritation, pain, fatigue, blurring and photophobia were assessed through a questionnaire. Tear film break-up time (BUT) and fluorescein corneal staining were investigated. Comparison among three groups and regression analysis of myopic error and other variables were conducted.
UNASSIGNED: Anisometropia and astigmatic error were greatest in the HM group compared with the other groups (p < 0.001). The HM group reported less photophobia (p < 0.001) and less pain (p = 0.039) compared with the NM group. Regression analysis revealed that myopic error was correlated with astigmatic error (β = -0.231, p <0.001), anisometropia (β = -0.191, p <0.001), short BUT (β = -0.086, p = 0.028) and the presence of diagnosed DED (β = -0.112, p = 0.003). Dryness (β = -0.127 p = 0.004), photophobia (β = 0.117, p = 0.002) and pain (β = 0.084, p = 0.034) correlated with myopic error.
UNASSIGNED: This study associated clinical findings of DED in HM teenagers. The present results suggest DED might be associated with myopia, possibly in a reciprocal relationship.
摘要：
■调查日本青少年的干眼病（DED）与近视之间的关系。
■这家诊所，回顾性,横断面研究评估了在日本眼科诊所就诊的10至19岁青少年的DED状况.他们包括106名高度近视患者(HM；平均年龄，16.4±2.2年)，494例轻度近视患者（15.0±2.6岁）和82例非近视青少年（NM；13.8±2.6岁）。测量主观屈光和屈光参差。近视分级为HM(≤-6.00D),MM(>-6.00D,<-0.50D),或NM（≥-0.5D）。DED相关症状的存在，包括干燥，刺激,疼痛,疲劳,模糊和畏光通过问卷进行评估.研究了泪膜破裂时间（BUT）和荧光素角膜染色。3组间比较,并对近视误差等变量进行回归分析。
■与其他组相比，HM组的屈光参差和散光误差最大（p<0.001）。与NM组相比，HM组报告了更少的畏光（p<0.001）和更少的疼痛（p=0.039）。回归分析显示近视误差与散光误差相关(β=-0.231,p<0.001),屈光参差（β=-0.191，p<0.001），短BUT（β=-0.086，p=0.028）和诊断DED的存在（β=-0.112，p=0.003）。干燥（β=-0.127p=0.004），畏光（β=0.117，p=0.002）和疼痛（β=0.084，p=0.034）与近视误差相关。
■这项研究与老年青少年DED的临床发现相关。目前的结果表明DED可能与近视有关，可能是一种互惠的关系。
■这家诊所，回顾性,横断面研究评估了在日本眼科诊所就诊的10至19岁青少年的DED状况.他们包括106名高度近视患者(HM；平均年龄，16.4±2.2年)，494例轻度近视患者（15.0±2.6岁）和82例非近视青少年（NM；13.8±2.6岁）。测量主观屈光和屈光参差。近视分级为HM(≤-6.00D),MM(>-6.00D,<-0.50D),或NM（≥-0.5D）。DED相关症状的存在，包括干燥，刺激,疼痛,疲劳,模糊和畏光通过问卷进行评估.研究了泪膜破裂时间（BUT）和荧光素角膜染色。3组间比较,并对近视误差等变量进行回归分析。
■与其他组相比，HM组的屈光参差和散光误差最大（p<0.001）。与NM组相比，HM组报告了更少的畏光（p<0.001）和更少的疼痛（p=0.039）。回归分析显示近视误差与散光误差相关(β=-0.231,p<0.001),屈光参差（β=-0.191，p<0.001），短BUT（β=-0.086，p=0.028）和诊断DED的存在（β=-0.112，p=0.003）。干燥（β=-0.127p=0.004），畏光（β=0.117，p=0.002）和疼痛（β=0.084，p=0.034）与近视误差相关。
■这项研究与老年青少年DED的临床发现相关。目前的结果表明DED可能与近视有关，可能是一种互惠的关系。
