Abstract：
The treatment of women aged 35 years and older with infertility applies assisted reproductive technologies (ART) in every third case. The purpose of the study is to analyze impact of maternal health on health of children who were delivered by women aged 35 years and older after application of ART. The analytical, direct observation, sociological (questioning), and statistical methods were applied. To study health status of children born after application of ART methods in women aged 35-45 years, representative main group of 648 preschool children (4-6 years old) was selected. The second control group included 649 preschool children (4-6 years old), who were as identical as possible to children from the main group, selected according to following characteristics: mother\'s age at birth of child (35-45 years), age (from 4 to 6 years), all were observed in same medical organization, birth from a singleton, full-term (37 weeks or more) pregnancy. The main and control groups differed from each other only in presence or absence of ART methods. The children born preterm, from egg donor programs and multiple pregnancies were excluded from study. The children health was studied according to medical examinations, medical records, child development history, and mothers questionnaire data on children health. The course of pregnancy and childbirth, morbidity and lifestyle characteristics of mothers were studied according to their questionnaires and copies of data from their outpatient medical records. It was established that there is direct correlation between health of child and health of mother (r = 0.571; p < 0.01, t = 3). At that, it was revealed that differences in level of general morbidity of children after ART and children from spontaneous pregnancy are achieved within account of significant differences in subgroup of children of mothers aged 38-45 years (3353.7‰ and 2341.8‰ control group).
摘要：
年龄在35岁及以上的不孕症妇女的治疗在每三分之一的病例中应用辅助生殖技术（ART）。该研究的目的是分析孕产妇健康对35岁及以上妇女在应用ART后分娩的儿童健康的影响。分析,直接观察,社会学（提问），并采用统计学方法。研究35-45岁女性应用ART方法后出生的儿童的健康状况，选择648名学龄前儿童（4-6岁）的代表性主要群体。第二对照组包括649名学龄前儿童（4-6岁），尽可能与主要群体的孩子相同，根据以下特征进行选择：母亲在孩子出生时的年龄（35-45岁），年龄（从4到6岁），都是在同一个医疗机构观察到的，从单身出生，足月（37周或以上）怀孕。主要组和对照组仅在存在或不存在ART方法时彼此不同。早产的孩子，从卵子供体计划和多胎妊娠被排除在研究之外.根据体检对儿童的健康状况进行了研究，医疗记录,儿童发展史,和母亲关于儿童健康的问卷调查数据。怀孕和分娩的过程，根据母亲的问卷调查和门诊医疗记录中的数据副本，研究了母亲的发病率和生活方式特征。确定儿童健康与母亲健康之间存在直接相关性（r=0.571；p<0.01，t=3）。在那,结果表明，由于38-45岁母亲的亚组（3353.7‰和2341.8‰对照组）的显着差异，ART后儿童和自然妊娠儿童的一般发病率水平存在差异。
