Abstract：
This year, we observe sixty\'s anniversary of the article by a British psychiatrist, Geoffrey Hartigan, demonstrating, for the first time, the possibility of preventing of the recurrence of mood disorders by using lithium salts. Herein, a history of prevention of recurrences of mood disorders both worldwide and in Poland will be presented concerning both lithium and other mood-stabilizing drugs. The merit for verifying the prophylactic lithium effect in the 1960-1970s should be given to Danish researchers, Mogens Schou and Poul Baastrup. In Poland, the first paper on prophylactic lithium appeared already in 1971. In the 1970s, French researchers showed prophylactic activity of valproic acid amide, and Japanese researchers - carbamazepine. In the 1980th, studies on valproic acid amide were performed in the 2nd Psychiatric Clinic of the Institute of Psychiatry and Neurology led by Prof. Pużyński. Since the mid-1990s, 2nd generation of mood-stabilizing drugs has been introduced, including some atypical antipsychotics (clozapine, olanzapine, quetiapine, aripiprazole, risperidone) and anticonvulsant drug, lamotrigine, showing prophylactic activity in bipolar mood disorder. The studies on lithium resulted in the identification of factors connected with its prophylactic efficacy as well as the antisuicidal, antiviral, and neuroprotective effects of this drug. From a sixty-year perspective following Hartigan\'s article, it seems that his pioneering concept on the possibility of pharmacological influence on the course of mood disorders was fully confirmed. Current Polish recommendations on pharmacological prophylaxis of mood disorders were presented in the books \"Standardy leczenia niektórych zaburzeń psychicznych\" and \"Psychofarmakologia kliniczna\", both published in 2022.
摘要：
今年,我们纪念一位英国精神病学家发表这篇文章的六十周年，GeoffreyHartigan,演示,第一次,通过使用锂盐预防情绪障碍复发的可能性。在这里，关于锂和其他情绪稳定药物，将介绍全球和波兰情绪障碍复发的预防史。验证1960-1970年代预防性锂效应的优点应该给予丹麦研究人员，MogensSchou和PoulBaastrup.在波兰,关于预防性锂的第一篇论文已经出现在1971年。在1970年代,法国研究人员显示了丙戊酸酰胺的预防活性，和日本研究人员-卡马西平。在1980年,丙戊酸酰胺的研究是在由教授领导的精神病学和神经病学研究所的第二精神病诊所进行的。普温斯基.自1990年代中期以来，第二代稳定情绪的药物已经推出，包括一些非典型抗精神病药（氯氮平，奥氮平,喹硫平,阿立哌唑,利培酮）和抗惊厥药物，拉莫三嗪,在双相情感障碍中表现出预防活性。对锂的研究导致确定与其预防功效以及抗自杀相关的因素，抗病毒，和这种药物的神经保护作用。在Hartigan的文章之后，从60年的角度来看，似乎他关于药理学影响情绪障碍过程的可能性的开创性概念得到了充分证实。波兰目前关于预防情绪障碍的药理学建议在“标准的lezzenianiektórychzaburzenpsychnych”和“Psychofarmakologiakliniczna”一书中提出，均于2022年出版。
