PDF(Pubmed)
Abstract：
Cannabigerol (CBG) is a phytocannabinoid increasing in popularity, with preclinical research indicating it has anxiolytic and antidepressant effects. However, there are no published clinical trials to corroborate these findings in humans. The primary objective of this study was to examine acute effects of CBG on anxiety, stress, and mood. Secondary objectives were to examine whether CBG produces subjective drug effects or motor and cognitive impairments. A double-blind, placebo-controlled cross-over field trial was conducted with 34 healthy adult participants. Participants completed two sessions (with a one-week washout period) via Zoom. In each, they provided ratings of anxiety, stress, mood, and subjective drug effects prior to double-blind administration of 20 mg hemp-derived CBG or placebo tincture (T0). These ratings were collected again after participants ingested the product and completed an online survey (T1), the Trier Social Stress Test (T2), a verbal memory test and the DRUID impairment app (T3). Relative to placebo, there was a significant main effect of CBG on overall reductions in anxiety as well as reductions in stress at T1. CBG also enhanced verbal memory relative to placebo. There was no evidence of subjective drug effects or impairment. CBG may represent a novel option to reduce stress and anxiety in healthy adults.
摘要：
大麻酚（CBG）是一种越来越受欢迎的植物大麻素，临床前研究表明它具有抗焦虑和抗抑郁作用。然而,没有发表的临床试验来证实这些发现在人类身上。这项研究的主要目的是检查CBG对焦虑的急性影响，压力，和心情。次要目标是检查CBG是否产生主观药物作用或运动和认知障碍。双盲，我们对34名健康成年参与者进行了安慰剂对照交叉现场试验.参与者通过Zoom完成了两次会议（为期一周的淘汰期）。在每一个,他们提供了焦虑的评级，压力，心情,在双盲给药20mg大麻衍生的CBG或安慰剂tin剂（T0）之前的主观药物效果。这些评级是在参与者摄入产品并完成在线调查（T1）后再次收集的，特里尔社会压力测试(T2)，语言记忆测试和药物损伤应用(T3)。相对于安慰剂，CBG对T1时焦虑和应激的整体降低有显著的主要作用.与安慰剂相比，CBG还增强了言语记忆。没有证据表明药物的主观作用或损害。CBG可能是减少健康成年人压力和焦虑的新选择。
