PDF(Pubmed)
Abstract：
Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease due to an autoimmune chronic inflammatory response, yet the etiology is currently not completely understood. It is already known that physical activity plays an essential role in improving quality of life, especially in neuropathological conditions. The study was aimed to investigate the possible benefits of high-intensity interval training (HIIT) in bone and lipid metabolism markers, and neuromotor abilities in MS patients. 130 participants were recruited; 16 subjects with MS met the inclusion criteria and were included in the data analysis. The patients were randomly assigned to two groups: a Control group (CG) (34.88 ± 4.45 yrs) that didn\'t perform any physical activity and the Exercise group (EG) (36.20 ± 7.80 yrs) that performed HIIT protocol. The training program was conducted remotely by a kinesiologist. It was performed three times a week for 8 weeks. At the beginning (T0) and the end of the study (T1) physical function tests, bone remodelling markers, and lipid markers analyses were performed. After 8 weeks of training the wall squat (s) (T0 = 27.18 ± 4.21; T1 = 41.68 ± 5.38, p ≤ 0.01) and Time Up and Go test (s) (T0 = 7.65 ± 0.43; T1 = 6.34 ± 0.38 p ≤ 0.01) performances improved; lipid markers analysis showed a decrease in Total (mg/dl) (T0 = 187.22 ± 15.73; T1 = 173.44 ± 13.03, p ≤ 0.05) and LDL (mg/dl) (T0 = 108 ± 21.08; T1 = 95.02 ± 17.99, p < 0.05) cholesterol levels. Additionally, the levels of osteocalcin (µg/L), a marker of bone formation increased (T0 = 20.88 ± 4.22; T1 = 23.66 ± 6.24, p < 0.05), 25-OH Vitamin D (µg/L) improved after 8 weeks (T0 = 21.11 ± 7.11; T1 = 27.66 ± 7.59, p < 0.05). HIIT had an effect on lower limb strength and gait control, improved bone formation, and lipid management, in MS patients.
摘要：
多发性硬化症（MS）是一种脱髓鞘和神经退行性疾病，由于自身免疫性慢性炎症反应，然而，目前尚未完全了解病因。众所周知，身体活动在提高生活质量方面起着至关重要的作用，尤其是在神经病理学条件下。该研究旨在探讨高强度间歇训练（HIIT）在骨骼和脂质代谢标志物中的可能益处，MS患者的神经运动能力。招募了130名参与者；16名MS受试者符合纳入标准，并纳入数据分析。患者被随机分为两组：对照组（CG）（34.88±4.45年），不进行任何身体活动，运动组（EG）（36.20±7.80年），执行HIIT方案。训练计划是由运动学家远程进行的。每周进行3次，共8周。在研究开始(T0)和结束(T1)身体功能测试时，骨骼重塑标记，和脂质标志物分析。训练8周后，壁深蹲（T0=27.18±4.21；T1=41.68±5.38，p≤0.01）和TimeUpandGotest（s）（T0=7.65±0.43；T1=6.34±0.38p≤0.01）性能得到改善；脂质标志物分析显示，总胆固醇（mg/dl）（T0=187.22±15.73；T1=173.44±108，p
