PDF(Pubmed)
Abstract：
BACKGROUND: Stimulating activities are associated with a decreased risk of dementia. However, the extent to which this reflects a protective effect of activity or non-participation resulting from dementia is debated. We investigated the association of stimulating leisure-time activity in late adulthood with the risk of dementia across up to two decades\' follow-up.
METHODS: We used data from five prospective cohort studies from Finland and Sweden. Mental, social, outdoor, consumptive and physical leisure-time activities were self-reported. Incident dementia was ascertained from clinical diagnoses or healthcare and death registers. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).
RESULTS: Of the 33 263 dementia-free individuals aged ≥50 years at baseline, 1408 had dementia during a mean follow-up of 7.0 years. Active participation in mental (HR: 0.52, 95% CI: 0.41 to 0.65), social (HR: 0.56 95% CI: 0.46 to 0.72), outdoor (HR: 0.70, 95% CI: 0.58 to 0.85), consumptive (HR: 0.67, 95% CI: 0.53 to 0.94) and physical (HR: 0.62, 95% CI: 0.51 to 0.75) activity, as well as variety (HR: 0.54, 95% CI: 0.43 to 0.68) and the overall frequency of activity (HR: 0.41, 95% CI: 0.34 to 0.49) were associated with a reduced risk of dementia in <10 years\' follow-up. In ≥10 years\' follow-up all associations attenuated toward the null.
CONCLUSIONS: Stimulating leisure-time activities are associated with a reduced risk of dementia in short-term but not long-term follow-up. These findings may reflect a reduction in leisure-time activity following preclinical dementia or dilution of the association over time.
METHODS: We used data from five prospective cohort studies from Finland and Sweden. Mental, social, outdoor, consumptive and physical leisure-time activities were self-reported. Incident dementia was ascertained from clinical diagnoses or healthcare and death registers. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).
RESULTS: Of the 33 263 dementia-free individuals aged ≥50 years at baseline, 1408 had dementia during a mean follow-up of 7.0 years. Active participation in mental (HR: 0.52, 95% CI: 0.41 to 0.65), social (HR: 0.56 95% CI: 0.46 to 0.72), outdoor (HR: 0.70, 95% CI: 0.58 to 0.85), consumptive (HR: 0.67, 95% CI: 0.53 to 0.94) and physical (HR: 0.62, 95% CI: 0.51 to 0.75) activity, as well as variety (HR: 0.54, 95% CI: 0.43 to 0.68) and the overall frequency of activity (HR: 0.41, 95% CI: 0.34 to 0.49) were associated with a reduced risk of dementia in <10 years\' follow-up. In ≥10 years\' follow-up all associations attenuated toward the null.
CONCLUSIONS: Stimulating leisure-time activities are associated with a reduced risk of dementia in short-term but not long-term follow-up. These findings may reflect a reduction in leisure-time activity following preclinical dementia or dilution of the association over time.
摘要：
背景：刺激活动与痴呆风险降低相关。然而,这在多大程度上反映了痴呆导致的活动或不参与的保护作用,目前仍存在争议.我们在长达20年的随访中调查了成年后期刺激闲暇时间活动与痴呆症风险的关系。
方法：我们使用了来自芬兰和瑞典的五项前瞻性队列研究的数据。心理,社会,户外,消费和体育休闲活动是自我报告的。从临床诊断或医疗保健和死亡登记中确定了痴呆事件。Cox回归用于估计风险比(HRs)和95%置信区间(CIs)。
结果：在基线时年龄≥50岁的33263名无痴呆个体中，1408在平均7.0年的随访期间患有痴呆症。积极参加精神活动（HR：0.52，95％CI：0.41至0.65），社会(HR：0.5695%CI：0.46至0.72)，户外(HR：0.70，95%CI：0.58至0.85)，消耗性（HR：0.67，95%CI：0.53至0.94）和身体活动（HR：0.62，95%CI：0.51至0.75），多样性(HR:0.54,95%CI:0.43~0.68)和总活动频率(HR:0.41,95%CI:0.34~0.49)与<10年随访期间痴呆风险降低相关.在≥10年的随访中，所有关联都向零衰减。
结论：在短期而非长期随访中，刺激闲暇时间活动与降低痴呆风险相关。这些发现可能反映了临床前痴呆后休闲时间活动的减少或随着时间的推移相关性的稀释。
方法：我们使用了来自芬兰和瑞典的五项前瞻性队列研究的数据。心理,社会,户外,消费和体育休闲活动是自我报告的。从临床诊断或医疗保健和死亡登记中确定了痴呆事件。Cox回归用于估计风险比(HRs)和95%置信区间(CIs)。
结果：在基线时年龄≥50岁的33263名无痴呆个体中，1408在平均7.0年的随访期间患有痴呆症。积极参加精神活动（HR：0.52，95％CI：0.41至0.65），社会(HR：0.5695%CI：0.46至0.72)，户外(HR：0.70，95%CI：0.58至0.85)，消耗性（HR：0.67，95%CI：0.53至0.94）和身体活动（HR：0.62，95%CI：0.51至0.75），多样性(HR:0.54,95%CI:0.43~0.68)和总活动频率(HR:0.41,95%CI:0.34~0.49)与<10年随访期间痴呆风险降低相关.在≥10年的随访中，所有关联都向零衰减。
结论：在短期而非长期随访中，刺激闲暇时间活动与降低痴呆风险相关。这些发现可能反映了临床前痴呆后休闲时间活动的减少或随着时间的推移相关性的稀释。
