Abstract：
Endocrine-disrupting chemicals (EDCs) are compounds, either natural or man-made, that interfere with the normal functioning of the endocrine system. There is increasing evidence that exposure to EDCs can have profound adverse effects on reproduction, metabolic disorders, neurological alterations, and increased risk of hormone-dependent cancer. Stem cells (SCs) are integral to these pathological processes, and it is therefore crucial to understand how EDCs may influence SC functionality. This review examines the literature on different types of EDCs and their effects on various types of SCs, including embryonic, adult, and cancer SCs. Possible molecular mechanisms through which EDCs may influence the phenotype of SCs are also evaluated. Finally, the possible implications of these effects on human health are discussed. The available literature demonstrates that EDCs can influence the biology of SCs in a variety of ways, including by altering hormonal pathways, DNA damage, epigenetic changes, reactive oxygen species production and alterations in the gene expression patterns. These disruptions may lead to a variety of cell fates and diseases later in adulthood including increased risk of endocrine disorders, obesity, infertility, reproductive abnormalities, and cancer. Therefore, the review emphasizes the importance of raising broader awareness regarding the intricate impact of EDCs on human health.
摘要：
内分泌干扰化学物质（EDC）是化合物，无论是自然的还是人造的，干扰内分泌系统的正常运作。越来越多的证据表明，暴露于EDCs会对生殖产生深远的不利影响，代谢紊乱，神经系统改变,激素依赖性癌症的风险增加。干细胞（SCs）是这些病理过程的组成部分，因此，了解EDC如何影响SC功能至关重要。本文综述了有关不同类型的EDC及其对各种类型的SC的影响的文献。包括胚胎，成人,和癌症SC。还评估了EDC可能影响SC表型的可能分子机制。最后,讨论了这些影响对人类健康的可能影响。现有文献表明，EDC可以通过多种方式影响SCs的生物学，包括通过改变荷尔蒙途径，DNA损伤,表观遗传变化,活性氧的产生和基因表达模式的改变。这些破坏可能导致多种细胞命运和疾病在成年后期，包括内分泌紊乱的风险增加，肥胖，不孕症,生殖异常，和癌症。因此,该审查强调了提高人们对EDC对人类健康的复杂影响的认识的重要性。
