Abstract：
Dermatosis papulosa nigra (DPN) is a type of benign epidermal hyperplasia that affects the appearance of patients and poses a threat to their physical and mental health. Photodynamic therapy (PDT) has been shown to have the advantages of non-invasiveness, efficacy, and low recurrence in the treatment of skin disorders. However, no studies have been reported on the use of PDT for the treatment of DPN. Therefore, we used PDT for the first time to treat DPN and monitor its efficacy. Forty-five patients with DPN diagnosed at the outpatient clinic of Changzhou First People\'s Hospital were treated with 10 % 5-aminolevulinic acid (ALA) once a week for four consecutive weeks and followed for 3 months. After four treatment sessions, the cure rate among the 45 patients was 71.1 %, and the overall efficacy rate was 93.3 %. The most common adverse reactions were mild erythema, edema, and temporary pigmentation. PDT is expected to become a new and effective treatment for DPN.
摘要：
黑丘疹皮肤病（DPN）是一种良性表皮增生，会影响患者的外观并威胁其身心健康。光动力疗法（PDT）已被证明具有非侵入性的优势，功效,和低复发的皮肤病的治疗。然而,尚无关于使用PDT治疗DPN的研究报告.因此,我们首次使用PDT治疗DPN并监测其疗效.在常州市第一人民医院门诊诊断的45例DPN患者接受10％5-氨基乙酰丙酸（ALA）治疗，每周1次，连续4周，随访3个月。经过四次治疗，45例患者的治愈率为71.1%,总有效率为93.3%。最常见的不良反应为轻度红斑,水肿,和暂时的色素沉着。PDT有望成为治疗DPN的一种新的有效方法。
