Abstract：
The development and growth of fish farming are hindered by viral and bacterial infectious diseases, which necessitate effective disease control measures. Furunculosis, primarily caused by Aeromonas salmonicida, stands out as a significant bacterial disease affecting salmonid fish farms, particularly rainbow trout. Vaccination has emerged as a crucial tool in combating this disease. The objective of this experiment was to assess and compare the efficacy and duration of different vaccine protocols against furunculosis in large trout under controlled rearing conditions, utilizing single and booster administrations via intraperitoneal, oral, and immersion routes. Among the various vaccination protocols tested, only those involving intraperitoneal injection, administered at least once, proved truly effective in preventing the expression of clinical signs of furunculosis and reducing mortality rates. A single intraperitoneal administration provided protection for up to 2352°-days, equivalent to approximately 5 months in water at 16 °C. However, intraperitoneal vaccination may lead to reduced growth in the fish due to resultant intraperitoneal adhesions. Additionally, protocols incorporating booster doses via intraperitoneal injection demonstrated efficacy regardless of the administration route of the primary vaccination. Nevertheless, the use of booster vaccinations via the intraperitoneal route did not confer any significant advantage over a single intraperitoneal injection in terms of efficacy.
摘要：
鱼类养殖的发展和生长受到病毒和细菌传染病的阻碍,这需要有效的疾病控制措施。糠疹,主要由沙门氏菌气单胞菌引起，作为一种影响鲑鱼养殖场的重大细菌性疾病，尤其是虹鳟鱼.疫苗接种已成为抗击这种疾病的重要工具。本实验的目的是评估和比较不同的疫苗方案在控制饲养条件下对大型鳟鱼的furunlosis的功效和持续时间。通过腹膜内单次和加强给药，口服,和沉浸路线。在测试的各种疫苗接种方案中，只有那些涉及腹膜内注射的，至少管理一次，事实证明，它确实有效地预防了糠疹的临床症状的表达并降低了死亡率。单次腹膜内给药可提供长达2352度-天的保护，相当于在16°C的水中约5个月。然而,腹膜内接种疫苗可导致由于所产生的腹膜内粘连导致的鱼生长减少。此外,无论初次疫苗接种的施用途径如何,通过腹膜内注射并入加强剂量的方案都显示出功效。然而，在疗效方面,通过腹膜内途径使用加强疫苗接种与单次腹膜内注射相比没有任何显著优势.
