Abstract：
Yersinia pestis is the causative agent of bubonic, septicemic and pneumonic plague. The historical importance and potential of plague to re-emerge as a threat worldwide are indisputable. The most severe manifestion of plague is pneumonic plague, which results in disease that is 100% lethal without treatment. Y. pestis suppresses host immune responses early in the lung to establish infection. The later stages of infection see the rapid onset of hyperinflammatory responses that prove lethal. The study of Y. pestis host/pathogen interactions have largely been investigated during bubonic plague and with attenuated strains in cell culture models. There remains a somewhat limited understanding of the interactions between virulent Y. pestis and immune populations in the lung that drive severe disease. In this review we give a broad overview of the progression of pneumonic plague and highlighting how Y. pestis interfaces with host innate immune populations in the lung to cause lethal disease.
摘要：
鼠疫耶尔森氏菌是引起鼠疫的病原体，败血症和肺鼠疫。鼠疫在世界范围内重新成为威胁的历史重要性和潜力是无可争辩的。鼠疫最严重的表现是肺鼠疫,这导致疾病是100%致命的不治疗。鼠疫耶尔森氏菌在肺部早期抑制宿主免疫反应以建立感染。在感染的后期，可以看到高炎症反应的快速发作，这证明是致命的。鼠疫耶尔森氏菌宿主/病原体相互作用的研究已在鼠疫期间进行了大量研究，并在细胞培养模型中使用了减毒株。对毒性鼠疫耶尔森氏菌和导致严重疾病的肺部免疫群体之间的相互作用的理解仍然有限。在这篇综述中，我们对肺鼠疫的进展进行了广泛的概述，并强调了鼠疫耶尔森氏菌如何与肺部的宿主先天免疫群体相互作用以引起致命疾病。
