PDF(Pubmed)
Abstract：
Leishmaniasis, a critical Neglected Tropical Disease caused by Leishmania protozoa, represents a significant global health risk, particularly in resource-limited regions. Conventional treatments are effective but suffer from serious limitations, such as toxicity, prolonged treatment courses, and rising drug resistance. Herein, we highlight the potential of inorganic nanomaterials as an innovative approach to enhance Leishmaniasis therapy, aligning with the One Health concept by considering these treatments\' environmental, veterinary, and public health impacts. By leveraging the adjustable properties of these nanomaterials─including size, shape, and surface charge, tailored treatments for various diseases can be developed that are less harmful to the environment and nontarget species. We review recent advances in metal-, oxide-, and carbon-based nanomaterials for combating Leishmaniasis, examining their mechanisms of action and their dual use as standalone treatments or drug delivery systems. Our analysis highlights a promising yet underexplored frontier in employing these materials for more holistic and effective disease management.
摘要：
利什曼病,利什曼原虫引起的严重被忽视的热带病，代表着重大的全球健康风险，特别是在资源有限的地区。常规治疗是有效的，但受到严重的限制，如毒性，延长疗程，和不断上升的抗药性。在这里，我们强调无机纳米材料作为增强利什曼病治疗的创新方法的潜力，通过考虑这些治疗方法，与“一个健康”的概念保持一致，兽医,和公共卫生影响。通过利用这些纳米材料的可调特性，包括尺寸，形状,和表面电荷，可以开发出对环境和非目标物种危害较小的针对各种疾病的定制治疗方法。我们回顾了金属的最新进展-，氧化物-,和用于防治利什曼病的碳基纳米材料，检查其作用机制及其作为独立治疗或药物输送系统的双重用途。我们的分析强调了在使用这些材料进行更全面和有效的疾病管理方面有前途但未充分开发的前沿。
