Abstract：
OBJECTIVE: Oral contraception is one of the most popular contraceptive methods both in adults and adolescents. However, the effects of oral contraception on lipids in adolescents are not well studied.
METHODS: Lipid profiles were measured and contraceptive use was assessed in 14- to 19-year-old female participants of the prospective population-based Early Vascular Ageing-Tyrol Study between 2015 and 2018, twice on average 22 months apart.
RESULTS: For this analysis, data from 828 young women with a median age of 17.0 years were available. Of them, 317 (38%) used oral contraceptives (OCs). OC users had a slightly higher systolic and diastolic blood pressure and larger changes over time and were more likely to use cigarettes than nonusers. Total cholesterol (179.6 vs. 162.4 mg/dL), low-density lipoprotein-cholesterol (106.4 vs. 94.6 mg/dL), and triglycerides (104.0 vs. 67.0 mg/dL) were significantly higher in OC users after multivariable adjustment in linear regression models. No difference in high-density lipoprotein-cholesterol between the two groups was found. In 558 females, follow-up data were available. Those who initiated OC use had on average 15.4 mg/dL higher low-density lipoprotein-cholesterol and 36.2 mg/dL higher triglyceride level changes between baseline and follow-up than never users. Duration of OC use did not show a significant association with lipid levels and changes.
CONCLUSIONS: We showed an independent association between OC use and blood lipids as well as lipid trajectories over time in a large cohort of healthy adolescents. These changes are especially relevant to consider in adolescents with other risk factors for dyslipidemia or other cardiovascular risk factors.
METHODS: Lipid profiles were measured and contraceptive use was assessed in 14- to 19-year-old female participants of the prospective population-based Early Vascular Ageing-Tyrol Study between 2015 and 2018, twice on average 22 months apart.
RESULTS: For this analysis, data from 828 young women with a median age of 17.0 years were available. Of them, 317 (38%) used oral contraceptives (OCs). OC users had a slightly higher systolic and diastolic blood pressure and larger changes over time and were more likely to use cigarettes than nonusers. Total cholesterol (179.6 vs. 162.4 mg/dL), low-density lipoprotein-cholesterol (106.4 vs. 94.6 mg/dL), and triglycerides (104.0 vs. 67.0 mg/dL) were significantly higher in OC users after multivariable adjustment in linear regression models. No difference in high-density lipoprotein-cholesterol between the two groups was found. In 558 females, follow-up data were available. Those who initiated OC use had on average 15.4 mg/dL higher low-density lipoprotein-cholesterol and 36.2 mg/dL higher triglyceride level changes between baseline and follow-up than never users. Duration of OC use did not show a significant association with lipid levels and changes.
CONCLUSIONS: We showed an independent association between OC use and blood lipids as well as lipid trajectories over time in a large cohort of healthy adolescents. These changes are especially relevant to consider in adolescents with other risk factors for dyslipidemia or other cardiovascular risk factors.
摘要：
目的：口服避孕是成人和青少年中最流行的避孕方法之一。然而,口服避孕药对青少年血脂的影响尚未得到充分研究.
方法：在2015年至2018年期间，在基于前瞻性人群的早期血管老化-蒂罗尔研究的14至19岁女性参与者中，测量了血脂谱并评估了避孕药具的使用，平均间隔22个月两次。
结果：对于此分析，我们获得了828名中位年龄为17.0岁的年轻女性的数据.其中,317（38％）使用口服避孕药（OC）。OC使用者的收缩压和舒张压略高，并且随着时间的推移变化更大，并且与非使用者相比更可能使用香烟。总胆固醇（179.6vs.162.4mg/dL)，低密度脂蛋白胆固醇（106.4vs.94.6mg/dL)，和甘油三酯（104.0vs.在线性回归模型中进行多变量调整后，OC使用者的67.0mg/dL）明显更高。两组之间的高密度脂蛋白-胆固醇没有差异。在558名女性中，随访数据可用。那些开始使用OC的人在基线和随访之间的低密度脂蛋白胆固醇平均高15.4mg/dL，甘油三酯水平变化高36.2mg/dL。OC使用的持续时间与脂质水平和变化没有显着关联。
结论：我们在一个大的健康青少年队列中显示，随着时间的推移，OC使用与血脂和血脂轨迹之间存在独立的关联。这些变化与考虑其他血脂异常或其他心血管危险因素的青少年尤其相关。
方法：在2015年至2018年期间，在基于前瞻性人群的早期血管老化-蒂罗尔研究的14至19岁女性参与者中，测量了血脂谱并评估了避孕药具的使用，平均间隔22个月两次。
结果：对于此分析，我们获得了828名中位年龄为17.0岁的年轻女性的数据.其中,317（38％）使用口服避孕药（OC）。OC使用者的收缩压和舒张压略高，并且随着时间的推移变化更大，并且与非使用者相比更可能使用香烟。总胆固醇（179.6vs.162.4mg/dL)，低密度脂蛋白胆固醇（106.4vs.94.6mg/dL)，和甘油三酯（104.0vs.在线性回归模型中进行多变量调整后，OC使用者的67.0mg/dL）明显更高。两组之间的高密度脂蛋白-胆固醇没有差异。在558名女性中，随访数据可用。那些开始使用OC的人在基线和随访之间的低密度脂蛋白胆固醇平均高15.4mg/dL，甘油三酯水平变化高36.2mg/dL。OC使用的持续时间与脂质水平和变化没有显着关联。
结论：我们在一个大的健康青少年队列中显示，随着时间的推移，OC使用与血脂和血脂轨迹之间存在独立的关联。这些变化与考虑其他血脂异常或其他心血管危险因素的青少年尤其相关。
