PDF(Pubmed)
Abstract：
BACKGROUND: Neuroendocrine neoplasms (NENs) are increasing in incidence globally. Previous analysis of the UK cancer database (National Cancer Registration and Analysis Service (NCRAS)) showed a notable female survival advantage in most tumour sites. This study aims to compare NCRAS to the Surveillance, Epidemiology, and End Results Program (SEER) to validate these results using the same statistical methods.
METHODS: A total of 14,834 and 108,399 patients with NENs were extracted from NCRAS and SEER, respectively. Sixty-months survival for both males and females for each anatomical site of NENs were calculated using restricted mean survival time (RMST) and Kaplan-Meier Survival estimates. The sixty-month RMST female survival advantage (FSA) was calculated.
RESULTS: FSA was similar in NCRAS and SEER. The highest FSA occurred in lung and stomach NENs.
CONCLUSIONS: The data from SEER confirm the findings published by NCRAS. Female survival advantage remains unexplained.
METHODS: A total of 14,834 and 108,399 patients with NENs were extracted from NCRAS and SEER, respectively. Sixty-months survival for both males and females for each anatomical site of NENs were calculated using restricted mean survival time (RMST) and Kaplan-Meier Survival estimates. The sixty-month RMST female survival advantage (FSA) was calculated.
RESULTS: FSA was similar in NCRAS and SEER. The highest FSA occurred in lung and stomach NENs.
CONCLUSIONS: The data from SEER confirm the findings published by NCRAS. Female survival advantage remains unexplained.
摘要：
背景：神经内分泌肿瘤（NENs）在全球范围内的发病率正在增加。先前对英国癌症数据库（国家癌症登记和分析服务（NCRAS））的分析显示，在大多数肿瘤部位，女性的生存优势显着。本研究旨在将NCRAS与监测进行比较，流行病学,和最终结果程序（SEER），以使用相同的统计方法验证这些结果。
方法：从NCRAS和SEER中提取了14,834和108,399例NENs患者，分别。使用限制平均生存时间（RMST）和Kaplan-Meier生存估计值计算NEN每个解剖部位的男性和女性的60个月生存率。计算60个月RMST女性生存优势(FSA)。
结果：FSA在NCRAS和SEER中相似。FSA最高发生在肺和胃NENs。
结论：来自SEER的数据证实了NCRAS发表的研究结果。女性生存优势仍然无法解释。
方法：从NCRAS和SEER中提取了14,834和108,399例NENs患者，分别。使用限制平均生存时间（RMST）和Kaplan-Meier生存估计值计算NEN每个解剖部位的男性和女性的60个月生存率。计算60个月RMST女性生存优势(FSA)。
结果：FSA在NCRAS和SEER中相似。FSA最高发生在肺和胃NENs。
结论：来自SEER的数据证实了NCRAS发表的研究结果。女性生存优势仍然无法解释。
