PDF(Pubmed)
Abstract：
A novel self-gelatinizing powder was designed to accelerate wound healing through enhanced hemostasis and tissue recovery. Significantly, this research addresses the critical need for innovative wound management solutions by presenting a novel approach. Carboxymethylcellulose calcium (CMC-Ca) was synthesized using an ion exchange method, and lysine (Lys) was integrated through physical mixing to augment the material\'s functional characteristics. The prepared powder underwent comprehensive evaluation for its self-gelling capacity, gelation time, adhesion, swelling rate, coagulation efficiency, hemostatic effectiveness, and wound healing promotion. Results indicate that the self-gelatinizing powder exhibited remarkable water absorption capabilities, absorbing liquid up to 30 times its weight and achieving rapid coagulation within 3 min. The inclusion of Lys notably enhanced the powder\'s gel-forming properties. The gelation time was determined to be within 4 s using a rotational rheometer, with the powder rapidly forming a stable gel on the skin surface. Furthermore, in a mouse skin injury model, near-complete skin recovery was observed within 14 days, underscoring the powder\'s impressive self-healing attributes and promising application prospects in wound management.
摘要：
设计了一种新型的自糊化粉末，通过增强止血和组织恢复来加速伤口愈合。重要的是,这项研究通过提出一种新颖的方法来解决对创新伤口管理解决方案的关键需求。采用离子交换法合成羧甲基纤维素钙(CMC-Ca),和赖氨酸（Lys）通过物理混合来增强材料的功能特性。对制备的粉末进行了自胶凝能力的综合评价，凝胶化时间，附着力,溶胀率,混凝效率,止血效果，和促进伤口愈合。结果表明，自糊化粉末表现出显著的吸水能力，吸收液体高达其重量的30倍，并在3分钟内实现快速凝固。Lys的加入显著增强了粉末的凝胶形成性能。使用旋转流变仪确定胶凝时间在4s内，粉末在皮肤表面迅速形成稳定的凝胶。此外，在小鼠皮肤损伤模型中，在14天内观察到接近完全的皮肤恢复，强调了粉末令人印象深刻的自我修复属性和在伤口管理中的应用前景。
