{Reference Type}: Journal Article
{Title}: Enhancing Wound Recovery: A Self-Gelling Powder for Improved Hemostasis and Healing.
{Author}: Zhao Y;Gao Y;Shen Z;Ni M;Xu J;Wang T;
{Journal}: Polymers (Basel)
{Volume}: 16
{Issue}: 13
{Year}: 2024 Jun 25
{Factor}: 4.967
{DOI}: 10.3390/polym16131795
{Abstract}: A novel self-gelatinizing powder was designed to accelerate wound healing through enhanced hemostasis and tissue recovery. Significantly, this research addresses the critical need for innovative wound management solutions by presenting a novel approach. Carboxymethylcellulose calcium (CMC-Ca) was synthesized using an ion exchange method, and lysine (Lys) was integrated through physical mixing to augment the material's functional characteristics. The prepared powder underwent comprehensive evaluation for its self-gelling capacity, gelation time, adhesion, swelling rate, coagulation efficiency, hemostatic effectiveness, and wound healing promotion. Results indicate that the self-gelatinizing powder exhibited remarkable water absorption capabilities, absorbing liquid up to 30 times its weight and achieving rapid coagulation within 3 min. The inclusion of Lys notably enhanced the powder's gel-forming properties. The gelation time was determined to be within 4 s using a rotational rheometer, with the powder rapidly forming a stable gel on the skin surface. Furthermore, in a mouse skin injury model, near-complete skin recovery was observed within 14 days, underscoring the powder's impressive self-healing attributes and promising application prospects in wound management.