PDF(Pubmed)
Abstract：
Visceral adipose tissue (VAT) dysfunction has been recently recognized as a potential contributor to the development of Alzheimer\'s disease (AD). This study aimed to explore the relationship between VAT metabolism and cerebral glucose metabolism in patients with cognitive impairment. This cross-sectional prospective study included 54 patients who underwent 18F-fluorodeoxyglucose (18F-FDG) brain and torso positron emission tomography/computed tomography (PET/CT), and neuropsychological evaluations. VAT metabolism was measured by 18F-FDG torso PET/CT, and cerebral glucose metabolism was measured using 18F-FDG brain PET/CT. A voxel-based analysis revealed that the high-VAT-metabolism group exhibited a significantly lower cerebral glucose metabolism in AD-signature regions such as the parietal and temporal cortices. In the volume-of-interest analysis, multiple linear regression analyses with adjustment for age, sex, and white matter hyperintensity volume revealed that VAT metabolism was negatively associated with cerebral glucose metabolism in AD-signature regions. In addition, higher VAT metabolism was correlated with poorer outcomes on cognitive assessments, including the Korean Boston Naming Test, Rey Complex Figure Test immediate recall, and the Controlled Oral Word Association Test. In conclusion, our study revealed significant relationships among VAT metabolism, cerebral glucose metabolism, and cognitive function. This suggests that VAT dysfunction actively contributes to the neurodegenerative processes characteristic of AD, making VAT dysfunction targeting a novel AD therapy approach.
摘要：
内脏脂肪组织（VAT）功能障碍最近被认为是阿尔茨海默病（AD）发展的潜在原因。本研究旨在探讨认知功能障碍患者VAT代谢与脑葡萄糖代谢的关系。这项横断面前瞻性研究包括54例接受18F-脱氧葡萄糖（18F-FDG）脑和躯干正电子发射断层扫描/计算机断层扫描（PET/CT）的患者，和神经心理学评估。通过18F-FDG躯干PET/CT测量增值税代谢，使用18F-FDG脑PET/CT测量脑葡萄糖代谢。基于体素的分析显示，高增值税代谢组在诸如顶叶和颞叶皮层等AD特征区域中表现出脑葡萄糖代谢显着降低。在兴趣量分析中，调整年龄的多元线性回归分析，性别,白质高强度容积显示，AD特征区域的VAT代谢与脑葡萄糖代谢呈负相关。此外,较高的增值税代谢与认知评估结果较差相关，包括韩国波士顿命名测试,ReyComplexFigureTest立即召回，和受控口头单词关联测试。总之,我们的研究揭示了增值税代谢之间的显著关系，脑葡萄糖代谢，和认知功能。这表明VAT功能障碍积极促进AD的神经退行性过程，使增值税功能障碍成为一种新的AD治疗方法。
