PDF(Pubmed)
Abstract：
Mood disorders affect over 300 million individuals worldwide, often characterized by their chronic and refractory nature, posing significant threats to patient life. There has been a notable increase in mood disorders among American adolescents and young adults, with a rising number of suicide attempts and fatalities, highlighting a growing association between mood disorders and suicidal outcomes. Dysregulation within the neuroimmune-endocrine system is now recognized as one of the fundamental biological mechanisms underlying mood and mood disorders. Lysophosphatidic acid (LPA), a novel mediator of mood behavior, induces anxiety-like and depression-like phenotypes through its receptors LPA1 and LPA5, regulating synaptic neurotransmission and plasticity. Consequently, LPA has garnered substantial interest in the study of mood regulation. This study aimed to elucidate the molecular mechanisms of lysophosphatidic acid and its receptors, along with LPA receptor ligands, in mood regulation and to explore their potential therapeutic efficacy in treating mood disorders. A comprehensive literature search was conducted using the PubMed and Web of Science databases, identifying 208 articles through keyword searches up to June 2024. After excluding duplicates, irrelevant publications, and those restricted by open access limitations, 21 scientific papers were included in this review. The findings indicate that LPA/LPA receptor modulation could be beneficial in treating mood disorders, suggesting that pharmacological agents or gintonin, an extract from ginseng, may serve as effective therapeutic strategies. This study opens new avenues for future research into how lysophosphatidic acid and its receptors, as well as lysophosphatidic acid receptor ligands, influence emotional behavior in animals and humans.
摘要：
情绪障碍影响着全球超过3亿人，通常以其慢性和难治性为特征，对患者生命构成重大威胁。美国青少年和年轻人的情绪障碍明显增加，随着自杀企图和死亡人数的增加，强调了情绪障碍和自杀结果之间日益增长的关联。神经免疫-内分泌系统内的失调现在被认为是情绪和情绪障碍的基本生物学机制之一。溶血磷脂酸(LPA),一种新颖的情绪行为调停者,通过其受体LPA1和LPA5诱导焦虑样和抑郁样表型，调节突触神经传递和可塑性。因此,LPA在情绪调节的研究中引起了极大的兴趣。本研究旨在阐明溶血磷脂酸及其受体的分子机制,以及LPA受体配体，并探讨其治疗情绪障碍的潜在疗效。使用PubMed和WebofScience数据库进行了全面的文献检索，到2024年6月，通过关键词搜索识别208篇文章。排除重复项之后,无关出版物，以及那些受到开放访问限制的人，本综述包括21篇科学论文。研究结果表明，LPA/LPA受体调节可能有益于治疗情绪障碍，这表明药物或肽素，从人参中提取,可以作为有效的治疗策略。这项研究为未来研究溶血磷脂酸及其受体如何，以及溶血磷脂酸受体配体，影响动物和人类的情绪行为。
