生长激素受体拮抗剂在人胰腺癌的小鼠异种移植模型中显著改善吉西他滨应答。
关键词: GH receptor (GHR) GHR antagonist adjuvant chemoresistance chemotherapy gemcitabine growth hormone (GH) insulin-like growth factor 1 (IGF1) pancreatic cancer pancreatic ductal adenocarcinoma
Mesh : Animals Gemcitabine Humans Deoxycytidine / analogs & derivatives pharmacology therapeutic use Pancreatic Neoplasms / drug therapy metabolism pathology genetics Mice Xenograft Model Antitumor Assays Receptors, Somatotropin / metabolism antagonists & inhibitors genetics Carcinoma, Pancreatic Ductal / drug therapy metabolism pathology genetics Cell Line, Tumor Mice, Nude Drug Resistance, Neoplasm / drug effects Gene Expression Regulation, Neoplastic / drug effects Female
来 源:
DOI:10.3390/ijms25137438
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