PDF(Pubmed)
Abstract：
Cytokines regulate immune responses and are crucial to MS pathogenesis. This study evaluated pro-inflammatory and anti-inflammatory cytokine concentrations in the CSF of de novo diagnosed RRMS patients compared to healthy controls. We assessed cytokine levels in the CSF of 118 de novo diagnosed RRMS patients and 112 controls, analyzing relationships with time from symptom onset to diagnosis, MRI lesions, and serum vitamin D levels. Elevated levels of IL-2, IL-4, IL-6, IL-13, FGF-basic, and GM-CSF, and lower levels of IL-1β, IL-1RA, IL-5, IL-7, IL-9, IL-10, IL-12p70, IL-15, G-CSF, PDGF-bb, and VEGF were observed in RRMS patients compared to controls. IL-2, IL-4, IL-12p70, PDGF, G-CSF, GM-CSF, and FGF-basic levels increased over time, while IL-10 decreased. IL-1β, IL-1RA, IL-6, TNF-α, and PDGF-bb levels negatively correlated with serum vitamin D. TNF-α levels positively correlated with post-contrast-enhancing brain lesions. IL-15 levels negatively correlated with T2 and Gd(+) lesions in C-spine MRI, while TNF-α, PDGF-bb, and FGF-basic correlated positively with T2 lesions in C-spine MRI. IL-6 levels positively correlated with post-contrast-enhancing lesions in Th-spine MRI. Distinct cytokine profiles in the CSF of de novo diagnosed MS patients provide insights into MS pathogenesis and guide immunomodulatory therapy strategies.
摘要：
细胞因子调节免疫反应，对MS发病机制至关重要。该研究评估了与健康对照相比的从头诊断的RRMS患者的CSF中的促炎和抗炎细胞因子浓度。我们评估了118名从头诊断的RRMS患者和112名对照的CSF中的细胞因子水平，分析从症状发作到诊断与时间的关系，MRI病变,和血清维生素D水平.IL-2，IL-4，IL-6，IL-13，FGF-碱性，和GM-CSF,和较低水平的IL-1β，IL-1RA,IL-5、IL-7、IL-9、IL-10、IL-12p70、IL-15、G-CSF、PDGF-bb,与对照组相比，在RRMS患者中观察到VEGF。IL-2，IL-4，IL-12p70，PDGF，G-CSF,GM-CSF,FGF基础水平随着时间的推移而增加，而IL-10下降。IL-1β,IL-1RA,IL-6,TNF-α,PDGF-bb水平与血清维生素D呈负相关。TNF-α水平与对比增强后的脑损伤呈正相关。C-脊柱MRI中IL-15水平与T2和Gd(+)病变呈负相关,而TNF-α,PDGF-bb,在C脊柱MRI中，FGF-basic与T2病变呈正相关。在Th脊柱MRI中，IL-6水平与对比增强后的病变呈正相关。从头诊断的MS患者的CSF中不同的细胞因子谱提供了对MS发病机理的见解并指导免疫调节治疗策略。
