PDF(Pubmed)
Abstract：
Small intestinal bacterial overgrowth (SIBO) is a pathology of the small intestine and may predispose individuals to various nutritional deficiencies. Little is known about whether specific subtypes of SIBO, such as the hydrogen-dominant (H+), methane-dominant (M+), or hydrogen/methane-dominant (H+/M+), impact nutritional status and dietary intake in SIBO patients. The aim of this study was to investigate possible correlations between biochemical parameters, dietary nutrient intake, and distinct SIBO subtypes. This observational study included 67 patients who were newly diagnosed with SIBO. Biochemical parameters and diet were studied utilizing laboratory tests and food records, respectively. The H+/M+ group was associated with low serum vitamin D (p < 0.001), low serum ferritin (p = 0.001) and low fiber intake (p = 0.001). The M+ group was correlated with high serum folic acid (p = 0.002) and low intakes of fiber (p = 0.001) and lactose (p = 0.002). The H+ group was associated with low lactose intake (p = 0.027). These results suggest that the subtype of SIBO may have varying effects on dietary intake, leading to a range of biochemical deficiencies. Conversely, specific dietary patterns may predispose one to the development of a SIBO subtype. The assessment of nutritional status and diet, along with the diagnosis of SIBO subtypes, are believed to be key components of SIBO therapy.
摘要：
小肠细菌过度生长（SIBO）是小肠的一种病理，可能使个体容易遭受各种营养缺乏。关于SIBO的特定亚型是否鲜为人知，如氢占优势(H+)，甲烷占优势(M+)，或氢/甲烷占优势（H+/M+），影响SIBO患者的营养状况和饮食摄入。这项研究的目的是研究生化参数之间可能的相关性，膳食营养素摄入量，和不同的SIBO亚型。这项观察性研究包括67例新诊断为SIBO的患者。生化参数和饮食研究利用实验室测试和食物记录，分别。H+/M+组血清维生素D水平低(p<0.001),低血清铁蛋白（p=0.001）和低纤维摄入量（p=0.001）。M+组与高血清叶酸(p=0.002)、低纤维(p=0.001)和低乳糖(p=0.002)相关。H+组与低乳糖摄入相关(p=0.027)。这些结果表明，SIBO的亚型可能对饮食摄入有不同的影响，导致一系列生化缺陷。相反，特定的饮食模式可能会导致SIBO亚型的发展。营养状况和饮食的评估，随着SIBO亚型的诊断，被认为是SIBO治疗的关键组成部分。
