PDF(Pubmed)
Abstract：
Achilles tendinopathy (TP) is characterized as the third most common disease of the musculoskeletal system, and occurs in three phases. There is currently no evidence of effective treatment for this medical condition. In this study, the modulatory effects of the minimally invasive technique intratissue percutaneous electrolysis (EPI) and combinations of EPI with four nutritional factors included in the diet, hydroxytyrosol (HT), maslinic acid (MA), glycine, and aspartate (AA), on hepatic intermediary metabolism was examined in Wistar rats with induced tendinopathy at various stages of TP. Results obtained showed that induced tendinopathy produced alterations in the liver intermediary metabolisms of the rats. Regarding carbohydrate metabolism, a reduction in the activity of pro-inflammatory enzymes in the later stages of TP was observed following treatment with EPI alone. Among the combined treatments using nutritional factors with EPI, HT+EPI and AA+EPI had the greatest effect on reducing inflammation in the late stages of TP. In terms of lipid metabolism, the HT+EPI and AA+EPI groups showed a decrease in lipogenesis. In protein metabolism, the HT+EPI group more effectively reduced the inflammatory effects of induced TP. Treatment with EPI combined with nutritional factors might help regulate intermediary metabolism in TP disease and reduce the inflammation process.
摘要：
跟腱病（TP）是肌肉骨骼系统的第三大常见疾病，发生在三个阶段。目前没有证据表明这种医疗状况可以有效治疗。在这项研究中,微创技术在经皮电解（EPI）和EPI与饮食中包含的四种营养因素的组合的调节作用，羟基酪醇（HT），山楂酸（MA），甘氨酸,和天冬氨酸（AA），在TP不同阶段的诱发肌腱病的Wistar大鼠中检查了肝脏中介代谢。获得的结果表明，诱发的肌腱病会改变大鼠的肝脏中间代谢。关于碳水化合物代谢，单独使用EPI治疗后,观察到TP后期促炎酶活性降低.在使用营养因子与EPI的联合治疗中，HT+EPI和AA+EPI对减轻TP晚期炎症的作用最大。在脂质代谢方面，HT+EPI和AA+EPI组脂肪生成减少。在蛋白质代谢中，HT+EPI组更有效地降低了TP诱导的炎症作用。EPI联合营养因子治疗可能有助于调节TP疾病的中介代谢，减少炎症过程。
