PDF(Pubmed)
Abstract：
Cancer development is related to genetic mutations in primary cells, where 5-10% of all cancers are derived from acquired genetic defects, most of which are a consequence of the environment and lifestyle. As it turns out, over half of cancer deaths are due to the generation of drug resistance. The local delivery of chemotherapeutic drugs may reduce their toxicity by increasing their therapeutic dose at targeted sites and by decreasing the plasma levels of circulating drugs. Nanobubbles have attracted much attention as an effective drug distribution system due to their non-invasiveness and targetability. This review aims to present the characteristics of nanobubble systems and their efficacy within the biomedical field with special emphasis on cancer treatment. In vivo and in vitro studies on cancer confirm nanobubbles\' ability and good blood capillary perfusion; however, there is a need to define their safety and side effects in clinical trials.
摘要：
癌症的发展与原代细胞的基因突变有关，其中5-10%的癌症来源于获得性遗传缺陷，其中大部分是环境和生活方式的结果。事实证明，超过一半的癌症死亡是由于耐药性的产生。化疗药物的局部递送可以通过增加其在靶向部位的治疗剂量和通过降低循环药物的血浆水平来降低其毒性。纳米气泡作为一种有效的药物分配系统，由于其非侵袭性和靶向性，已经引起了广泛的关注。这篇综述旨在介绍纳米气泡系统的特征及其在生物医学领域的功效，特别着重于癌症治疗。对癌症的体内和体外研究证实了纳米气泡的能力和良好的血液毛细血管灌注；然而，有必要在临床试验中确定其安全性和副作用.
