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Abstract：
Breast cancer represents the most prevalent form of cancer and the leading cause of cancer-related mortality among females worldwide. It has been reported that several risk factors contribute to the appearance and progression of this disease. Despite the advancements in breast cancer treatment, a significant portion of patients with distant metastases still experiences no cure. The extracellular matrix represents a potential target for enhanced serum biomarkers in breast cancer. Furthermore, extracellular matrix degradation and epithelial-mesenchymal transition constitute the primary stages of local invasion during tumorigenesis. Additionally, the microbiome has a potential influence on diverse physiological processes. It is emerging that microbial dysbiosis is a significant element in the development and progression of various cancers, including breast cancer. Thus, a better understanding of extracellular matrix and microbiome interactions could provide novel alternatives to breast cancer treatment and management. In this review, we summarize the current evidence regarding the intricate relationship between breast cancer with the extracellular matrix and the microbiome. We discuss the arising associations and future perspectives in this field.
摘要：
乳腺癌是最普遍的癌症形式，也是全球女性癌症相关死亡率的主要原因。据报道，几种危险因素有助于这种疾病的出现和进展。尽管在乳腺癌治疗方面取得了进展，大部分远处转移患者仍无法治愈.细胞外基质代表了乳腺癌中增强的血清生物标志物的潜在靶标。此外，细胞外基质降解和上皮间质转化是肿瘤发生过程中局部侵袭的主要阶段。此外,微生物组对不同的生理过程有潜在的影响。微生物菌群失调是各种癌症发展和进展的重要因素，包括乳腺癌.因此，更好地了解细胞外基质和微生物组的相互作用可以为乳腺癌的治疗和管理提供新的替代方案.在这次审查中,我们总结了目前关于乳腺癌与细胞外基质和微生物组之间复杂关系的证据。我们讨论了该领域中出现的关联和未来的观点。
