PDF(Pubmed)
Abstract：
Madhuca longifolia is an evergreen tree distributed in India, Nepal, and Sri Lanka. This tree is commonly known as Mahua and is used in traditional medicine. It was demonstrated that ethanol extract from the bark of M. longifolia possessed potent cytotoxic activity towards two melanoma cell lines, in contrast to aqueous extract that exhibited no activity. Apart from being selectively cytotoxic to cancer cells (with no activity towards non-cancerous fibroblasts), the studied extract induced apoptosis and increased reactive oxygen species generation in melanoma cells. Additionally, the use of the extract together with dacarbazine (both in non-toxic concentrations) resulted in the enhancement of their anticancer activity. Moreover, the pretreatment of melanoma cells with M. longifolia extract potentiated the activity of a low dose of dacarbazine to an even higher extent. It was concluded that ethanol extract of M. longifolia sensitized human melanoma cells to chemotherapeutic drugs. It can therefore be interesting as a promising source of compounds for prospective combination therapy.
摘要：
Madhucalongifolia是一种分布在印度的常绿乔木，尼泊尔,和斯里兰卡。这种树通常被称为麻花，用于传统医学。已证明，来自M.longifolia树皮的乙醇提取物对两种黑色素瘤细胞系具有有效的细胞毒性活性，与没有活性的水提取物相反。除了对癌细胞有选择性的细胞毒性（对非癌性成纤维细胞没有活性），所研究的提取物诱导细胞凋亡和增加黑色素瘤细胞中活性氧的产生。此外,提取物与达卡巴嗪（均为无毒浓度）一起使用可增强其抗癌活性。此外，用长叶分枝杆菌提取物预处理黑素瘤细胞可在更大程度上增强低剂量达卡巴嗪的活性。结论：长叶分枝杆菌的乙醇提取物对人黑色素瘤细胞对化疗药物敏感。因此,作为用于预期联合治疗的化合物的有希望的来源,它是令人感兴趣的。
