PDF(Pubmed)
Abstract：
Infections, such as that by the multiresistant opportunistic bacterial pathogen Pseudomonas aeruginosa, may pose a serious health risk, especially on vulnerable patient populations. The nematode Caenorhabditis elegans provides a simple organismal model to investigate both pathogenic mechanisms and the emerging role of innate immunity in host protection. Here, we review the virulence and infection strategies of P. aeruginosa and host defenses of C. elegans. We summarize the recognition mechanisms of patterns of pathogenesis, including novel pathogen-associated molecular patterns and surveillance immunity of translation, mitochondria, and lysosome-related organelles. We also review the regulation of antimicrobial and behavioral defenses by the worm\'s neuroendocrine system. We focus on how discoveries in this rich field align with well-characterized evolutionary conserved protective pathways, as well as on potential crossovers to human pathogenesis and innate immune responses.
摘要：
感染,例如多重耐药机会性细菌病原体铜绿假单胞菌，可能会带来严重的健康风险，特别是对脆弱的患者群体。线虫秀丽隐杆线虫提供了一种简单的有机模型来研究致病机制和先天免疫在宿主保护中的新兴作用。这里,我们综述了铜绿假单胞菌的毒力和感染策略以及秀丽隐杆线虫的宿主防御。我们总结了发病模式的识别机制，包括新的病原体相关分子模式和监测免疫的翻译，线粒体,和溶酶体相关的细胞器.我们还回顾了蠕虫的神经内分泌系统对抗菌和行为防御的调节。我们专注于在这个丰富领域的发现如何与特征明确的进化保守保护途径相一致，以及与人类发病机理和先天免疫反应的潜在交叉。
