SAHA / 5 - AZA 增强胰腺癌细胞中 mutp53 的乙酰化和降解 , 上调 p21 并下调 c - Myc 和 BRCA - 1 。
关键词: DNA damage acetylation c-Myc methylation mutp53 pancreatic cancer
Mesh : Humans Pancreatic Neoplasms / metabolism drug therapy genetics pathology Acetylation / drug effects Cell Line, Tumor Proto-Oncogene Proteins c-myc / metabolism genetics Vorinostat / pharmacology BRCA1 Protein / metabolism genetics Cyclin-Dependent Kinase Inhibitor p21 / metabolism genetics Gene Expression Regulation, Neoplastic / drug effects Tumor Suppressor Protein p53 / metabolism genetics Azacitidine / pharmacology Down-Regulation / drug effects Proteolysis / drug effects Up-Regulation / drug effects Histone Deacetylase Inhibitors / pharmacology
来 源:
DOI:10.3390/ijms25137020
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