关键词: carcinogenesis cobalt copper heavy metals iron manganese zinc

Mesh : Humans Neoplasms / metabolism Trace Elements Animals Carcinogenesis / drug effects Cell Proliferation / drug effects Neovascularization, Pathologic / drug therapy

来  源:   DOI:10.3390/ijms25136842   PDF(Pubmed)

Abstract:
This study examines the impact of zinc, copper, cobalt, iron, and manganese on cancer development, considering their dual roles as potential promoters or inhibitors within tumorigenesis. A comprehensive analysis of existing literature and experimental data is conducted to elucidate the intricate relationship between these trace elements and cancer progression. The findings highlight the multifaceted effects of zinc, copper, cobalt, iron, and manganese on various aspects of cancer development, including cell proliferation, angiogenesis, and metastasis. Understanding the nuanced interactions between these trace elements and cancer could offer crucial insights into tumorigenesis mechanisms and facilitate the identification of novel biomarkers and therapeutic targets for cancer prevention and treatment strategies. This research underscores the importance of considering the roles of essential trace elements in cancer biology and may ultimately contribute to advancements in precision medicine approaches for combating cancer.
摘要:
这项研究检查了锌的影响,铜,钴,铁,和锰对癌症发展的影响,考虑它们在肿瘤发生中作为潜在的启动子或抑制剂的双重作用。对现有文献和实验数据进行了全面分析,以阐明这些微量元素与癌症进展之间的复杂关系。研究结果强调了锌的多方面影响,铜,钴,铁,和锰对癌症发展的各个方面,包括细胞增殖,血管生成,和转移。了解这些微量元素与癌症之间的细微相互作用可以为肿瘤发生机制提供重要见解,并有助于识别癌症预防和治疗策略的新型生物标志物和治疗靶标。这项研究强调了考虑必需微量元素在癌症生物学中的作用的重要性,并可能最终有助于精准医学方法的进步。
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