PDF(Pubmed)
Abstract：
Extensive research has explored the functional correlation between stem cells and progenitor cells, particularly in blood. Hematopoietic stem cells (HSCs) can self-renew and regenerate tissues within the bone marrow, while stromal cells regulate tissue function. Recent studies have validated the role of mammalian stem cells within specific environments, providing initial empirical proof of this functional phenomenon. The interaction between bone and blood has always been vital to the function of the human body. It was initially proposed that during evolution, mammalian stem cells formed a complex relationship with the surrounding microenvironment, known as the niche. Researchers are currently debating the significance of molecular-level data to identify individual stromal cell types due to incomplete stromal cell mapping. Obtaining these data can help determine the specific activities of HSCs in bone marrow. This review summarizes key topics from previous studies on HSCs and their environment, discussing current and developing concepts related to HSCs and their niche in the bone marrow.
摘要：
广泛的研究探索了干细胞和祖细胞之间的功能相关性，尤其是在血液中。造血干细胞（HSC）可以自我更新和再生骨髓内的组织，而基质细胞调节组织功能。最近的研究已经验证了哺乳动物干细胞在特定环境中的作用，为这种功能现象提供初步的经验证明。骨骼和血液之间的相互作用一直对人体的功能至关重要。最初有人提出，在进化过程中，哺乳动物干细胞与周围的微环境形成了复杂的关系,被称为利基。研究人员目前正在争论分子水平数据的重要性，以识别由于不完整的基质细胞作图而导致的单个基质细胞类型。获得这些数据可以帮助确定骨髓中HSC的特异性活性。这篇综述总结了以往关于HSC及其环境的研究的关键主题，讨论与HSC及其在骨髓中的生态位相关的当前和发展中的概念。
