PDF(Pubmed)
Abstract：
Urinary tract infections (UTIs) are the most common bacterial infections in postmenopausal women, and women with diabetes are possibly at a higher risk. The aim of this study is to evaluate the potential benefit on the prevention of UTI episodes, assessed by urinalysis and urine culture (primary outcome) after two, four and six months, of daily oral dietary supplement (120 mg highly standardized cranberry extract phytosome), compared to placebo, in diabetic postmenopausal women taking SGLT-2 inhibitors. Forty-six subjects (mean age 72.45 ± 1.76) completed the study (23 placebo/23 supplement). Considering UTI episodes, during the six-month supplementation period, an increase of 1.321 (95% CI: -0.322; 2.9650) was observed in the placebo group, while it remained at a steady value of 0.393 (95% CI: -4.230; 5.016) in the supplemented group. Regarding UTI episodes, in both groups, interaction between times for supplementation was statistically significant (p = 0.001). In particular, at follow-up 4, 9% of the placebo group showed infection versus only 3% with cranberry supplementation. Glycaemia and glycated hemoglobin values (secondary outcomes) were not modified at the end of six months with respect to the basal values in both groups, as expected. While in terms of quality of life per the SF-12 health questionnaire, there were no differences between the two groups, an improvement in SF-12 quality of life was observed in both groups (six months vs. basal). In conclusion, highly standardized cranberry extract phytosome supplementation reduced UTI recurrence.
摘要：
尿路感染（UTI）是绝经后妇女最常见的细菌感染，糖尿病患者的风险可能更高。这项研究的目的是评估预防UTI发作的潜在益处，通过尿液分析和尿液培养（主要结果）评估，四个月又六个月,每日口服膳食补充剂（120毫克高度标准化的蔓越莓提取物植物体），与安慰剂相比，在糖尿病绝经后妇女服用SGLT-2抑制剂。46名受试者(平均年龄72.45±1.76)完成了研究(23名安慰剂/23名补充剂)。考虑到UTI发作,在六个月的补充期间，在安慰剂组中观察到1.321（95％CI：-0.322;2.9650）的增加，而在补充组中它保持在0.393（95％CI：-4.230;5.016）的稳定值。关于UTI发作，在这两组中，补充时间之间的交互作用有统计学意义(p=0.001).特别是,在随访4时,安慰剂组有9%出现感染,而酸果蔓补充剂组只有3%出现感染.在6个月结束时，两组的血糖和糖化血红蛋白值（次要结局）相对于基础值没有改变。如预期。而就SF-12健康问卷的生活质量而言，两组之间没有差异,两组均观察到SF-12生活质量的改善(6个月vs.基底)。总之,高度标准化的蔓越莓提取物植物体补充剂减少UTI复发。
