PDF(Pubmed)
Abstract：
BACKGROUND: Circadian Syndrome (CircS) encompasses cardiometabolic risk factors and comorbidities, indicating an elevated susceptibility to cardiovascular disease and type 2 diabetes.
METHODS: This cross-sectional study aimed to investigate the association between vitamin D levels and each of the following: CircS, metabolic syndrome (MetS), and the individual components of CircS. Data from 14,907 adults who participated in the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2018 were utilized. CircS was defined based on MetS components, alongside depression, short sleep, and non-alcoholic fatty liver disease (NAFLD).
RESULTS: Our results indicated that low vitamin D levels exhibited meaningful associations with CircS, with vitamin D deficiency and inadequacy demonstrating 2.21-fold (95% CI 1.78-2.74, p < 0.001) and 1.33-fold (95% CI 1.14-1.54, p < 0.001) increases in CircS odds, respectively. The association between vitamin D deficiency and CircS was stronger than that with MetS. Additionally, a dose-response gradient in odds of CircS components, particularly with short sleep duration, was noted as serum vitamin D levels decreased.
CONCLUSIONS: our findings highlight a significant association between low serum vitamin D levels and CircS and its components, particularly with short sleep. This suggests a potentially pivotal role of vitamin D in the pathogenesis of Circadian syndrome.
METHODS: This cross-sectional study aimed to investigate the association between vitamin D levels and each of the following: CircS, metabolic syndrome (MetS), and the individual components of CircS. Data from 14,907 adults who participated in the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2018 were utilized. CircS was defined based on MetS components, alongside depression, short sleep, and non-alcoholic fatty liver disease (NAFLD).
RESULTS: Our results indicated that low vitamin D levels exhibited meaningful associations with CircS, with vitamin D deficiency and inadequacy demonstrating 2.21-fold (95% CI 1.78-2.74, p < 0.001) and 1.33-fold (95% CI 1.14-1.54, p < 0.001) increases in CircS odds, respectively. The association between vitamin D deficiency and CircS was stronger than that with MetS. Additionally, a dose-response gradient in odds of CircS components, particularly with short sleep duration, was noted as serum vitamin D levels decreased.
CONCLUSIONS: our findings highlight a significant association between low serum vitamin D levels and CircS and its components, particularly with short sleep. This suggests a potentially pivotal role of vitamin D in the pathogenesis of Circadian syndrome.
摘要：
背景：昼夜节律综合征（Circasts）包括心脏代谢危险因素和合并症，表明对心血管疾病和2型糖尿病的易感性升高。
方法：这项横断面研究旨在调查维生素D水平与以下各项之间的关联：代谢综合征（MetS），以及CircS的各个组成部分。利用了2007年至2018年参加国家健康和营养检查调查（NHANES）的14,907名成年人的数据。CircS是基于MetS组件定义的，除了抑郁症，短暂的睡眠,和非酒精性脂肪性肝病（NAFLD）。
结果：我们的结果表明，低维生素D水平与CircS，维生素D缺乏和不足时，CircS几率增加2.21倍（95％CI1.78-2.74，p<0.001）和1.33倍（95％CI1.14-1.54，p<0.001），分别。维生素D缺乏与CircS之间的关联比与MetS之间的关联更强。此外,CircS成分几率的剂量反应梯度，特别是在睡眠时间短的情况下，注意到血清维生素D水平下降。
结论：我们的发现强调了低血清维生素D水平与CircS及其组分之间的显著关联，特别是睡眠时间短。这表明维生素D在昼夜节律综合征的发病机制中潜在的关键作用。
方法：这项横断面研究旨在调查维生素D水平与以下各项之间的关联：代谢综合征（MetS），以及CircS的各个组成部分。利用了2007年至2018年参加国家健康和营养检查调查（NHANES）的14,907名成年人的数据。CircS是基于MetS组件定义的，除了抑郁症，短暂的睡眠,和非酒精性脂肪性肝病（NAFLD）。
结果：我们的结果表明，低维生素D水平与CircS，维生素D缺乏和不足时，CircS几率增加2.21倍（95％CI1.78-2.74，p<0.001）和1.33倍（95％CI1.14-1.54，p<0.001），分别。维生素D缺乏与CircS之间的关联比与MetS之间的关联更强。此外,CircS成分几率的剂量反应梯度，特别是在睡眠时间短的情况下，注意到血清维生素D水平下降。
结论：我们的发现强调了低血清维生素D水平与CircS及其组分之间的显著关联，特别是睡眠时间短。这表明维生素D在昼夜节律综合征的发病机制中潜在的关键作用。
