PDF(Pubmed)
Abstract：
BACKGROUND: Our search for plant-derived ceramides from sustainable sources led to the discovery of ceramides and glucosylceramides in wine lees.
OBJECTIVE: This study evaluated the efficacy and safety of wine lees extract (WLE)-derived ceramides and glucosylceramides in enhancing skin barrier function.
METHODS: A randomized, double-blind, placebo-controlled study was conducted with 30 healthy Japanese subjects aged 20-64. Subjects were allocated to receive either the WLE-derived ceramides and glucosylceramides (test group) or placebo for 12 weeks. The primary outcome was transepidermal water loss (TEWL), and secondary outcomes included skin hydration, visual analog scale (VAS) of itching sensation, and the Japanese Skindex-29.
RESULTS: One participant withdrew for personal reasons, resulting in 29 subjects for data analysis (placebo n = 15; test n = 14). The test group showed a tendency of lower TEWL compared to the placebo after 8 weeks (p = 0.07). Furthermore, after 12 weeks of administration, the test group had significantly lower TEWL than the placebo (p = 0.04). On the other hand, no significant differences were observed in the secondary outcome parameters. No adverse events related to the supplements were reported.
CONCLUSIONS: Oral supplementation of WLE-derived ceramides and glucosylceramides is a prominent and safe approach to enhancing skin barrier function and health.
BACKGROUND: (UMIN000050422).
OBJECTIVE: This study evaluated the efficacy and safety of wine lees extract (WLE)-derived ceramides and glucosylceramides in enhancing skin barrier function.
METHODS: A randomized, double-blind, placebo-controlled study was conducted with 30 healthy Japanese subjects aged 20-64. Subjects were allocated to receive either the WLE-derived ceramides and glucosylceramides (test group) or placebo for 12 weeks. The primary outcome was transepidermal water loss (TEWL), and secondary outcomes included skin hydration, visual analog scale (VAS) of itching sensation, and the Japanese Skindex-29.
RESULTS: One participant withdrew for personal reasons, resulting in 29 subjects for data analysis (placebo n = 15; test n = 14). The test group showed a tendency of lower TEWL compared to the placebo after 8 weeks (p = 0.07). Furthermore, after 12 weeks of administration, the test group had significantly lower TEWL than the placebo (p = 0.04). On the other hand, no significant differences were observed in the secondary outcome parameters. No adverse events related to the supplements were reported.
CONCLUSIONS: Oral supplementation of WLE-derived ceramides and glucosylceramides is a prominent and safe approach to enhancing skin barrier function and health.
BACKGROUND: (UMIN000050422).
摘要：
背景：我们从可持续来源中寻找植物衍生的神经酰胺导致在酒糟中发现了神经酰胺和葡萄糖基神经酰胺。
目的：本研究评估了酒糟提取物（WLE）衍生的神经酰胺和葡萄糖神经酰胺在增强皮肤屏障功能方面的功效和安全性。
方法：随机，双盲,对30名年龄在20-64岁的日本健康受试者进行了安慰剂对照研究.受试者被分配接受WLE衍生的神经酰胺和葡萄糖基神经酰胺（测试组）或安慰剂12周。主要结果是经表皮水分流失（TEWL），次要结果包括皮肤水合作用，瘙痒感的视觉模拟量表（VAS），和日本Skindex-29。
结果：一名参与者因个人原因退出，结果29名受试者进行数据分析（安慰剂n=15；测试n=14）。8周后,与安慰剂相比,试验组显示出TEWL降低的趋势(p=0.07)。此外，给药12周后，试验组的TEWL显著低于安慰剂组(p=0.04).另一方面,次要结局参数无显著差异.没有报告与补充剂相关的不良事件。
结论：口服补充WLE衍生的神经酰胺和葡萄糖基神经酰胺是增强皮肤屏障功能和健康的突出且安全的方法。
背景：（UMIN000050422）。
目的：本研究评估了酒糟提取物（WLE）衍生的神经酰胺和葡萄糖神经酰胺在增强皮肤屏障功能方面的功效和安全性。
方法：随机，双盲,对30名年龄在20-64岁的日本健康受试者进行了安慰剂对照研究.受试者被分配接受WLE衍生的神经酰胺和葡萄糖基神经酰胺（测试组）或安慰剂12周。主要结果是经表皮水分流失（TEWL），次要结果包括皮肤水合作用，瘙痒感的视觉模拟量表（VAS），和日本Skindex-29。
结果：一名参与者因个人原因退出，结果29名受试者进行数据分析（安慰剂n=15；测试n=14）。8周后,与安慰剂相比,试验组显示出TEWL降低的趋势(p=0.07)。此外，给药12周后，试验组的TEWL显著低于安慰剂组(p=0.04).另一方面,次要结局参数无显著差异.没有报告与补充剂相关的不良事件。
结论：口服补充WLE衍生的神经酰胺和葡萄糖基神经酰胺是增强皮肤屏障功能和健康的突出且安全的方法。
背景：（UMIN000050422）。
