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Abstract：
Microscopic colitis (MC) and coeliac disease (CD) are common associated gastrointestinal conditions. We present the largest study assessing hospitalisation in patients with MC and the effect of a concomitant diagnosis of CD. Data were retrospectively collected between January 2007 and December 2021 from all patients diagnosed with MC and compared to a database of patients with only CD. In total, 892 patients with MC (65% female, median age 65 years (IQR: 54-74 years) were identified, with 6.4% admitted to hospital due to a flare of MC. Patients admitted were older (76 vs. 65 years, p < 0.001) and presented with diarrhoea (87.7%), abdominal pain (26.3%), and acute kidney injury (17.5%). Treatment was given in 75.9% of patients, including intravenous fluids (39.5%), steroids (20.9%), and loperamide (16.3%). Concomitant CD was diagnosed in 3.3% of patients and diagnosed before MC (57 versus 64 years, p < 0.001). Patients with both conditions were diagnosed with CD later than patients with only CD (57 years versus 44 years, p < 0.001). In conclusion, older patients are at a higher risk of hospitalisation due to MC, and this is seen in patients with a concomitant diagnosis of CD too. Patients with MC are diagnosed with CD later than those without.
摘要：
显微镜结肠炎（MC）和乳糜泻（CD）是常见的相关胃肠道疾病。我们提供了一项最大的研究，该研究评估了MC患者的住院情况以及伴随CD诊断的影响。在2007年1月至2021年12月期间，从所有诊断为MC的患者中回顾性收集数据，并与仅患有CD的患者的数据库进行比较。总的来说,892例MC（65%为女性，中位年龄65岁（IQR：54-74岁）被确定，6.4%的患者因MC发作入院。入院的患者年龄较大（76vs.65岁,p<0.001)，并出现腹泻(87.7%)，腹痛（26.3%），和急性肾损伤（17.5%）。75.9%的患者接受了治疗，包括静脉输液(39.5%)，类固醇（20.9%），和洛哌丁胺（16.3%）。3.3%的患者诊断为合并CD，并在MC之前诊断（57岁对64岁，p<0.001)。患有这两种疾病的患者比仅患有CD的患者晚被诊断为CD（57岁对44岁，p<0.001)。总之,老年患者因MC住院的风险较高，这也见于同时诊断为CD的患者。患有MC的患者诊断为CD的时间比没有的患者晚。
