Abstract:
Microscopic colitis (MC) and coeliac disease (CD) are common associated gastrointestinal conditions. We present the largest study assessing hospitalisation in patients with MC and the effect of a concomitant diagnosis of CD. Data were retrospectively collected between January 2007 and December 2021 from all patients diagnosed with MC and compared to a database of patients with only CD. In total, 892 patients with MC (65% female, median age 65 years (IQR: 54-74 years) were identified, with 6.4% admitted to hospital due to a flare of MC. Patients admitted were older (76 vs. 65 years, p < 0.001) and presented with diarrhoea (87.7%), abdominal pain (26.3%), and acute kidney injury (17.5%). Treatment was given in 75.9% of patients, including intravenous fluids (39.5%), steroids (20.9%), and loperamide (16.3%). Concomitant CD was diagnosed in 3.3% of patients and diagnosed before MC (57 versus 64 years, p < 0.001). Patients with both conditions were diagnosed with CD later than patients with only CD (57 years versus 44 years, p < 0.001). In conclusion, older patients are at a higher risk of hospitalisation due to MC, and this is seen in patients with a concomitant diagnosis of CD too. Patients with MC are diagnosed with CD later than those without.
摘要:
显微镜结肠炎(MC)和乳糜泻(CD)是常见的相关胃肠道疾病。我们提供了一项最大的研究,该研究评估了MC患者的住院情况以及伴随CD诊断的影响。在2007年1月至2021年12月期间,从所有诊断为MC的患者中回顾性收集数据,并与仅患有CD的患者的数据库进行比较。总的来说,892例MC(65%为女性,中位年龄65岁(IQR:54-74岁)被确定,6.4%的患者因MC发作入院。入院的患者年龄较大(76vs.65岁,p<0.001),并出现腹泻(87.7%),腹痛(26.3%),和急性肾损伤(17.5%)。75.9%的患者接受了治疗,包括静脉输液(39.5%),类固醇(20.9%),和洛哌丁胺(16.3%)。3.3%的患者诊断为合并CD,并在MC之前诊断(57岁对64岁,p<0.001)。患有这两种疾病的患者比仅患有CD的患者晚被诊断为CD(57岁对44岁,p<0.001)。总之,老年患者因MC住院的风险较高,这也见于同时诊断为CD的患者。患有MC的患者诊断为CD的时间比没有的患者晚。