PDF(Pubmed)
Abstract：
BACKGROUND: Oral nutritional supplements (ONSs) are crucial for supporting the nutritional needs of pediatric populations, particularly those with medical conditions or dietary deficiencies. Bioactive compounds within ONSs play a pivotal role in enhancing health outcomes by exerting various physiological effects beyond basic nutrition. However, the comprehensive understanding of these bioactives in pediatric ONSs remains elusive.
OBJECTIVE: This systematic narrative review aims to critically evaluate the existing literature concerning bioactive compounds present in oral nutritional supplements from a pediatric standpoint, focusing on their types, sources, bioavailability, physiological effects, and clinical implications.
METHODS: A systematic search was conducted across the major academic databases, including PubMed, Scopus, and Web of Science, employing predefined search terms related to oral nutritional supplements, bioactives, and pediatrics. Studies published between 2013 and 2024 were considered eligible for inclusion. Data extraction and synthesis were performed according to the PRISMA guidelines.
RESULTS: The initial search yielded 558 of articles, of which 72 met the inclusion criteria. The included studies encompassed a diverse range of bioactive compounds present in pediatric ONS formulations, including, but not limited to, vitamins, minerals, amino acids, prebiotics, probiotics, and phytonutrients. These bioactives were sourced from various natural and synthetic origins and were found to exert beneficial effects on growth, development, immune function, gastrointestinal health, cognitive function, and overall well-being in pediatric populations. However, variations in bioavailability, dosing, and clinical efficacy were noted across different compounds and formulations.
CONCLUSIONS: Bioactive compounds in oral nutritional supplements offer promising avenues for addressing the unique nutritional requirements and health challenges faced by pediatric populations. However, further research is warranted to elucidate the optimal composition, dosage, and clinical applications of these bioactives in pediatric ONS formulations. A deeper understanding of these bioactive compounds and their interplay with pediatric health may pave the way for personalized and effective nutritional interventions in pediatric clinical practice.
OBJECTIVE: This systematic narrative review aims to critically evaluate the existing literature concerning bioactive compounds present in oral nutritional supplements from a pediatric standpoint, focusing on their types, sources, bioavailability, physiological effects, and clinical implications.
METHODS: A systematic search was conducted across the major academic databases, including PubMed, Scopus, and Web of Science, employing predefined search terms related to oral nutritional supplements, bioactives, and pediatrics. Studies published between 2013 and 2024 were considered eligible for inclusion. Data extraction and synthesis were performed according to the PRISMA guidelines.
RESULTS: The initial search yielded 558 of articles, of which 72 met the inclusion criteria. The included studies encompassed a diverse range of bioactive compounds present in pediatric ONS formulations, including, but not limited to, vitamins, minerals, amino acids, prebiotics, probiotics, and phytonutrients. These bioactives were sourced from various natural and synthetic origins and were found to exert beneficial effects on growth, development, immune function, gastrointestinal health, cognitive function, and overall well-being in pediatric populations. However, variations in bioavailability, dosing, and clinical efficacy were noted across different compounds and formulations.
CONCLUSIONS: Bioactive compounds in oral nutritional supplements offer promising avenues for addressing the unique nutritional requirements and health challenges faced by pediatric populations. However, further research is warranted to elucidate the optimal composition, dosage, and clinical applications of these bioactives in pediatric ONS formulations. A deeper understanding of these bioactive compounds and their interplay with pediatric health may pave the way for personalized and effective nutritional interventions in pediatric clinical practice.
摘要：
背景：口服营养补充剂（ONS）对于支持儿科人群的营养需求至关重要，特别是那些有医疗条件或饮食不足的人。ONS中的生物活性化合物通过发挥超出基本营养的各种生理作用，在增强健康结果方面发挥着关键作用。然而,对儿科ONS中这些生物活性物质的全面了解仍然难以捉摸。
目的：本系统叙述性综述旨在从儿科的角度对现有的关于口服营养补充剂中生物活性化合物的文献进行批判性评价。专注于他们的类型，来源,生物利用度，生理效应,和临床意义。
方法：在主要的学术数据库中进行了系统的搜索，包括PubMed,Scopus,和WebofScience,采用与口服营养补充剂相关的预定义搜索词，生物活性物质,和儿科。2013年至2024年发表的研究被认为符合纳入条件。根据PRISMA指南进行数据提取和合成。
结果：最初的搜索产生了558篇文章，其中72人符合纳入标准。纳入的研究涵盖了儿科ONS制剂中存在的各种生物活性化合物，包括,但不限于,维生素,矿物,氨基酸,益生元,益生菌，和植物营养素。这些生物活性物质来自各种天然和合成来源，并被发现对生长产生有益影响。发展,免疫功能，肠胃健康,认知功能,以及儿科人群的总体幸福感。然而,生物利用度的变化，给药,在不同的化合物和制剂中观察到临床疗效。
结论：口服营养补充剂中的生物活性化合物为解决儿科人群面临的独特营养需求和健康挑战提供了有希望的途径。然而,进一步的研究是必要的，以阐明最佳的组成，剂量,以及这些生物活性物质在儿科ONS制剂中的临床应用。更深入地了解这些生物活性化合物及其与儿科健康的相互作用可能为儿科临床实践中个性化和有效的营养干预铺平道路。
目的：本系统叙述性综述旨在从儿科的角度对现有的关于口服营养补充剂中生物活性化合物的文献进行批判性评价。专注于他们的类型，来源,生物利用度，生理效应,和临床意义。
方法：在主要的学术数据库中进行了系统的搜索，包括PubMed,Scopus,和WebofScience,采用与口服营养补充剂相关的预定义搜索词，生物活性物质,和儿科。2013年至2024年发表的研究被认为符合纳入条件。根据PRISMA指南进行数据提取和合成。
结果：最初的搜索产生了558篇文章，其中72人符合纳入标准。纳入的研究涵盖了儿科ONS制剂中存在的各种生物活性化合物，包括,但不限于,维生素,矿物,氨基酸,益生元,益生菌，和植物营养素。这些生物活性物质来自各种天然和合成来源，并被发现对生长产生有益影响。发展,免疫功能，肠胃健康,认知功能,以及儿科人群的总体幸福感。然而,生物利用度的变化，给药,在不同的化合物和制剂中观察到临床疗效。
结论：口服营养补充剂中的生物活性化合物为解决儿科人群面临的独特营养需求和健康挑战提供了有希望的途径。然而,进一步的研究是必要的，以阐明最佳的组成，剂量,以及这些生物活性物质在儿科ONS制剂中的临床应用。更深入地了解这些生物活性化合物及其与儿科健康的相互作用可能为儿科临床实践中个性化和有效的营养干预铺平道路。
