PDF(Pubmed)
Abstract：
High-sensitivity C-reactive protein (hs-CRP) is a widely used clinical biomarker of systemic inflammation, implicated in many chronic conditions, including type 1 diabetes (T1D). Despite the increasing emphasis on dietary intake as a modifiable risk factor for systemic inflammation, the association of hs-CRP with fruit and vegetable consumption is relatively underexplored in T1D. To address this gap, we investigated the longitudinal associations of dietary pattern-derived fruit and vegetable scores with hs-CRP in adults with and without T1D. Additionally, we examined the impact of berry consumption as a distinct food group. Data were collected in the Coronary Artery Calcification in Type 1 Diabetes study over two visits that were three years apart. At each visit, participants completed a food frequency questionnaire, and hs-CRP was measured using a particle-enhanced immunonephelometric assay. Mixed effect models were used to examine the three-year association of fruit and vegetable scores with hs-CRP. Adjusted models found a significant inverse association between blueberry intake and hs-CRP in the nondiabetic (non-DM) group. Dietary Approaches to Stop Hypertension- and Alternative Healthy Eating Index-derived vegetable scores were also inversely associated with hs-CRP in the non-DM group (all p-values ≤ 0.05). Conversely, no significant associations were observed in the T1D group. In conclusion, dietary pattern-derived vegetable scores are inversely associated with hs-CRP in non-DM adults. Nonetheless, in T1D, chronic hyperglycemia and related metabolic abnormalities may override the cardioprotective features of these food groups at habitually consumed servings.
摘要：
超敏C反应蛋白(hs-CRP)是广泛使用的全身性炎症的临床生物标志物,与许多慢性病有关，包括1型糖尿病（T1D）。尽管人们越来越重视饮食摄入作为全身性炎症的可改变的危险因素，在T1D中,hs-CRP与水果和蔬菜消费的相关性相对缺乏.为了解决这个差距，我们调查了有和没有T1D的成人中膳食模式衍生的水果和蔬菜评分与hs-CRP的纵向关联.此外,我们研究了浆果消费作为一个独特的食物群体的影响。在1型糖尿病的冠状动脉钙化研究中收集了间隔三年的两次访问的数据。每次访问,参与者完成了食物频率问卷，和hs-CRP使用颗粒增强的免疫比浊法测定。使用混合效应模型来检查水果和蔬菜评分与hs-CRP的三年关联。调整后的模型发现，在非糖尿病（非DM）组中，蓝莓摄入量与hs-CRP之间存在显着负相关。在非DM组中，停止高血压和替代健康饮食指数得出的蔬菜评分与hs-CRP呈负相关（所有p值≤0.05）。相反，在T1D组中没有观察到显著的相关性.总之,在非DM成人中,基于膳食模式的蔬菜评分与hs-CRP呈负相关.尽管如此，在T1D中，慢性高血糖和相关的代谢异常可能会在习惯性食用的食物中超越这些食物组的心脏保护特征.
