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Abstract：
Background: Colorectal cancer is the third most common cancer worldwide, and 20-30% of patients will develop liver metastases (CRLM) during their lifetime. Hepatocellular carcinoma (HCC) is also one of the most common cancers worldwide with increasing incidence. Hepatic resection represents the most effective treatment approach for both CRLM and HCC. Recently, sarcopenia has gained popularity as a prognostic index in order to assess the perioperative risk of hepatectomies. The aim of this study is to assess the effects of sarcopenia on the overall survival (OS), complication rates and mortality of patients undergoing liver resections for HCC or CRLM. Methods: A systematic literature search was performed for studies including patients undergoing hepatectomy for HCC or CRLM, and a meta-analysis of the data was performed. Results: Sarcopenic patients had a significantly lower 5-year OS compared to non-sarcopenic patients (43.8% vs. 63.6%, respectively; p < 0.01) and a significantly higher complication rate (35.4% vs. 23.1%, respectively; p = 0.002). Finally, no statistical correlation was found in mortality between sarcopenic and non-sarcopenic patients (p > 0.1). Conclusions: Sarcopenia was significantly associated with decreased 5-year OS and increased morbidity, but no difference was found with regard to postoperative mortality.
摘要：
背景:结直肠癌是全球第三大常见癌症,20-30%的患者会在其一生中发生肝转移(CRLM)。肝细胞癌（HCC）也是全球最常见的癌症之一，发病率越来越高。肝切除术是CRLM和HCC最有效的治疗方法。最近,为了评估肝切除术的围手术期风险，肌少症已成为预后指标。这项研究的目的是评估少肌症对总生存期（OS）的影响。肝癌或CRLM肝切除术患者的并发症发生率和死亡率。方法：进行了系统的文献检索研究，包括接受肝癌或CRLM肝切除术的患者，并对数据进行荟萃分析.结果：与非肌肉减少患者相比，肌肉减少患者的5年OS显着降低（43.8％vs.63.6%,分别；p<0.01）和明显更高的并发症发生率（35.4%vs.23.1%,分别为；p=0.002)。最后,无统计学相关性(p>0.1)。结论：肌肉减少症与5年OS降低和发病率增加显著相关。但术后死亡率无差异.
