PDF(Pubmed)
Abstract：
Background: Pericardial and pleural effusions are two complications recently described in patients hospitalized with COVID-19 infections. There are several mechanisms that have been proposed and refer to SARS-CoV-2\'s capacity to bind to cell surfaces via various receptors and its broad tissue tropism that might cause significant complications. The aim of the present study is to evaluate the incidence of pericardial and pleural effusions during COVID-19 infection as well as to determine the risk factors associated with these complications. Methods: We conducted a retrospective single-center study that included 346 patients admitted to the National Institute of Infectious Disease \"Prof. Dr. Matei Bals\" (Bucharest, Romania), from 1 January to 25 May 2021, during the third wave of the pandemic. Socio-demographic and anthropometric data were collected for each patient. The patients were evaluated clinically, biologically, and radiologically within 48 h of admission. Patients were divided into 3 groups: (1) patients with pericardial effusions-18; (2) patients with pleural effusions-28; (3) patients without pericardial/pleural effusions-294. Results: After exclusion criteria were applied, 337 patients were analyzed. The median age of the participants was 58.26 ± 14.58 years. More than half of the hospitalized patients had associated respiratory failure (61.5%), of which 2.7% had a critical form of the disease and 58.8% had a severe form. The cumulative percentage for pericardial and pleural effusions for the study group was 12.8% (43 patients out of 337). The prevalence of pericardial effusion was 5.3%, twice more frequent among male respondents. Pleural effusion was identified in 8.3% patients. Most patients had unilateral effusion (17), compared to 11 patients who had bilateral involvement. Based on laboratory results, patients with pericardial and pleural effusions exhibited increased levels of C reactive protein, erythrocyte sedimentation rate, NT proBNP, and a higher value of neutrophil/lymphocyte count ratio. In contrast to patients without pleural and pericardial effusions, those with these symptoms experienced a higher frequency of severe or critical illness and longer hospital stays. Conclusions: Pericardial and pleural effusions can complicate COVID-19 infections. In our study, the prevalence of pericardial and pleural effusions in hospitalized patients was low, being associated with the same comorbidities and a number of clinical and biological parameters.
摘要：
背景：心包和胸腔积液是最近在COVID-19感染住院患者中描述的两种并发症。已经提出了几种机制，并提到SARS-CoV-2通过各种受体结合细胞表面的能力及其广泛的组织嗜性，这可能导致严重的并发症。本研究的目的是评估COVID-19感染期间心包和胸腔积液的发生率，并确定与这些并发症相关的危险因素。方法：我们进行了一项回顾性的单中心研究，包括了美国国家传染病研究所收治的346例患者。马蒂·巴尔斯博士（布加勒斯特，罗马尼亚),从2021年1月1日至5月25日，在第三波大流行期间。收集每位患者的社会人口统计学和人体测量数据。对患者进行了临床评估，生物学，并在入院48小时内进行放射学检查。患者分为3组：（1）心包积液患者-18；（2）胸腔积液患者-28；（3）没有心包/胸腔积液的患者-294。结果：应用排除标准后，对337例患者进行了分析。参与者的中位年龄为58.26±14.58岁。超过一半的住院患者有相关的呼吸衰竭（61.5%），其中2.7%患有严重形式的疾病，58.8%患有严重形式的疾病。研究组心包和胸腔积液的累积百分比为12.8%(337例中有43例患者)。心包积液的发生率为5.3%,男性受访者的频率要高出两倍。8.3%的患者出现胸腔积液。大多数患者有单侧积液（17），与11例双侧受累患者相比。根据实验室结果,心包和胸腔积液患者的C反应蛋白水平升高，红细胞沉降率,NTproBNP,中性粒细胞/淋巴细胞计数比值较高。与没有胸膜和心包积液的患者相比，有这些症状的患者出现严重或危重疾病的频率更高，住院时间更长。结论：心包和胸腔积液可使COVID-19感染复杂化。在我们的研究中,住院患者心包和胸腔积液的患病率较低，与相同的合并症以及许多临床和生物学参数有关。
