PDF(Pubmed)
Abstract：
Plant diseases caused by pathogenic fungi seriously affect the yield and quality of crops, cause huge economic losses, and pose a considerable threat to global food security. Phenylpyrrole analogues were designed and synthesized based on alkaloid lycogalic acid. All target compounds were characterized by 1H NMR, 13C NMR, and HRMS. Their antifungal activities against seven kinds of phytopathogenic fungi were evaluated. The results revealed that most compounds had broad-spectrum fungicidal activities at 50 μg/mL; 14 compounds displayed more than 60% fungicidal activities against Rhizoctonia cerealis and Sclerotinia sclerotiorum, and in particular, the fungicidal activities of compounds 8g and 8h against Rhizoctonia cerealis were more than 90%, which could be further developed as lead agents for water-soluble fungicides. The molecular docking results indicate that compounds 8g and 8h can interact with 14α-demethylase (RcCYP51) through hydrogen bonding with strong affinity.
摘要：
病原真菌引起的植物病害严重影响作物的产量和品质,造成巨大的经济损失，并对全球粮食安全构成相当大的威胁。基于生物碱白麦酸设计并合成了苯基吡咯类似物。所有目标化合物通过1HNMR表征,13CNMR,和HRMS。评价了它们对7种植物病原真菌的抗真菌活性。结果表明，大多数化合物在50μg/mL时具有广谱抗菌活性；14个化合物对谷物根瘤菌和核盘菌具有60%以上的杀菌活性，特别是,化合物8g和8h对小麦根瘤菌的杀菌活性均在90%以上,可进一步开发为水溶性杀菌剂的先导剂。分子对接结果表明，化合物8g和8h可以通过氢键与14α-脱甲基酶（RcCYP51）相互作用，具有很强的亲和力。
