PDF(Pubmed)
Abstract：
Antipsychotic medications are essential for managing severe mental illnesses like schizophrenia, which impacts about 1% of the global population. Despite efficacy, in some cases, they can induce hyperprolactinemia, affecting roughly half of the patients. The prevalence of this condition varies with the specific medication used. Although prolactinomas are rare among schizophrenia patients, treating them with dopamine agonists poses conflicts with antipsychotic medication, necessitating careful monitoring and adjustments. The aim of this study was to explore the presence of brain tumors, prolactinomas, and other structural brain changes in schizophrenia patients treated with second-generation antipsychotics using cerebral computed tomography (CT) scans. We conducted a cross-sectional study involving 152 hospitalized patients diagnosed between 1 January 2020 and 31 March 2024. Evaluations included cerebral CT scans, prolactin level assessments, and the monitoring of side effects. Patients, with an average age of 42.79 years and an illness duration of 17.89 years, predominantly received olanzapine (46.05%) and risperidone (36.84%). Side effects, reported by 61.78% of patients, included tremors, dizziness, and weight gain. Abnormal prolactin levels were observed in 53.95% of patients, more prevalent in females on risperidone and in both genders on olanzapine. No prolactinomas were detected on CT scans. Managing hyperprolactinemia in schizophrenia patients undergoing antipsychotic therapy is essential to prevent long-term complications and to ensure treatment compliance.
摘要：
抗精神病药物对于治疗精神分裂症等严重精神疾病至关重要，这影响了全球约1%的人口。尽管有效,在某些情况下,它们可以诱发高催乳素血症，影响了大约一半的患者。这种情况的患病率因使用的特定药物而异。尽管在精神分裂症患者中泌乳素瘤很少见，用多巴胺激动剂治疗它们会与抗精神病药物发生冲突，需要仔细监测和调整。这项研究的目的是探索脑肿瘤的存在，泌乳素瘤,使用脑计算机断层扫描（CT）扫描使用第二代抗精神病药治疗的精神分裂症患者的大脑结构变化。我们进行了一项横断面研究，涉及2020年1月1日至2024年3月31日诊断的152名住院患者。评估包括脑部CT扫描，催乳素水平评估，以及副作用的监测。患者,平均年龄42.79岁，患病时间17.89岁，主要接受奥氮平（46.05％）和利培酮（36.84％）。副作用,61.78%的患者报告，包括震颤,头晕,和体重增加。53.95%的患者泌乳素水平异常,利培酮在女性和奥氮平在两种性别中都更普遍。CT扫描未检测到催乳素瘤。在接受抗精神病药物治疗的精神分裂症患者中管理高催乳素血症对于预防长期并发症和确保治疗依从性至关重要。
