PDF(Pubmed)
Abstract：
Results obtained in physics, chemistry and materials science on nanoparticles have drawn significant interest in the use of nanostructures on dental implants. The main focus concerns nanoscale surface modifications of titanium-based dental implants in order to increase the surface roughness and provide a better bone-implant interfacial area. Surface coatings via the sol-gel process ensure the deposition of a homogeneous layer of nanoparticles or mixtures of nanoparticles on the titanium substrate. Nanotubular structures created on the titanium surface by anodic oxidation yield an interesting nanotopography for drug release. Carbon-based nanomaterials hold great promise in the field of dentistry on account of their outstanding mechanical properties and their structural characteristics. Carbon nanomaterials that include carbon nanotubes, graphene and its derivatives (graphene oxide and graphene quantum dots) can be used as coatings of the implant surface. Their antibacterial properties as well as their ability to be functionalized with adequate chemical groups make them particularly useful for improving biocompatibility and promoting osseointegration. Nevertheless, an evaluation of their possible toxicity is required before being exploited in clinical trials.
摘要：
在物理学中获得的结果，化学和材料科学的纳米粒子已经引起了极大的兴趣，在牙科植入物使用纳米结构。主要关注钛基牙种植体的纳米级表面改性，以增加表面粗糙度并提供更好的骨-种植体界面面积。通过溶胶-凝胶工艺的表面涂层确保了在钛基材上沉积纳米颗粒或纳米颗粒混合物的均匀层。通过阳极氧化在钛表面上产生的纳米管状结构产生了用于药物释放的有趣的纳米形貌。碳基纳米材料因其优异的机械性能和结构特征而在牙科领域具有广阔的前景。碳纳米材料，包括碳纳米管，石墨烯及其衍生物(氧化石墨烯和石墨烯量子点)可以用作植入物表面的涂层。它们的抗菌性能以及它们被足够的化学基团官能化的能力使得它们对于改善生物相容性和促进骨整合特别有用。然而，在进行临床试验之前，需要对其可能的毒性进行评估。
