通过谷胱甘肽衍生的碳点从氧化应激微环境中拯救髓核细胞以减轻椎间盘退变。
关键词: Cellular senescence Glutathione-doped carbon dot nanozymes Inflammation Intervertebral disc degeneration Oxidative stress Reactive oxygen species
Mesh : Intervertebral Disc Degeneration / drug therapy metabolism pathology Nucleus Pulposus / metabolism drug effects pathology Animals Oxidative Stress / drug effects Carbon / chemistry pharmacology Glutathione / metabolism Reactive Oxygen Species / metabolism Quantum Dots / chemistry Antioxidants / pharmacology Male Cellular Senescence / drug effects Cells, Cultured Humans Mitochondria / metabolism drug effects Cellular Microenvironment / drug effects Catalase / metabolism pharmacology Superoxide Dismutase / metabolism
来 源:
DOI:10.1186/s12951-024-02683-2
PDF(Pubmed)