PDF(Pubmed)
Abstract：
BACKGROUND: The present study aimed to assess how a concentrated growth factor (CGF) injection affects the rate of orthodontic tooth movement in rabbits.
METHODS: This experimental investigation employed a split-mouth configuration. Before orthodontic mesialization of the maxillary first molars, CGF was prepared and administered using submucosal injections on the buccal and palatal sides of the maxillary first molars in one randomly assigned quadrant. The opposite quadrant was used as a control. The study examined four time points:1, 2, 3, and 4 weeks. The measurement of tooth movement was conducted at each follow-up point using a digital caliper. The rabbits were euthanized, and their maxillary segments, specifically the maxillary first molars, were studied histologically to identify any alterations occurring on both the tension and compression sides.
RESULTS: Significant tooth movement was observed in the experimental sides versus control sides in the second, third, and fourth week of follow-up periods (p ≤ 0.05). Histologically, on the compression side, the CGF group showed bone resorption and periodontal ligament active reactions from the first week and continued throughout the next three weeks. Also, on the tension side, the CGF group depicted cementoblastic and osteoblastic activities from the first week followed by fibroblastic activities from the second week and all activities continued till the fourth week.
CONCLUSIONS: CGF has the potential to effectively enhance orthodontic tooth movement without adverse clinical or histological effects.
METHODS: This experimental investigation employed a split-mouth configuration. Before orthodontic mesialization of the maxillary first molars, CGF was prepared and administered using submucosal injections on the buccal and palatal sides of the maxillary first molars in one randomly assigned quadrant. The opposite quadrant was used as a control. The study examined four time points:1, 2, 3, and 4 weeks. The measurement of tooth movement was conducted at each follow-up point using a digital caliper. The rabbits were euthanized, and their maxillary segments, specifically the maxillary first molars, were studied histologically to identify any alterations occurring on both the tension and compression sides.
RESULTS: Significant tooth movement was observed in the experimental sides versus control sides in the second, third, and fourth week of follow-up periods (p ≤ 0.05). Histologically, on the compression side, the CGF group showed bone resorption and periodontal ligament active reactions from the first week and continued throughout the next three weeks. Also, on the tension side, the CGF group depicted cementoblastic and osteoblastic activities from the first week followed by fibroblastic activities from the second week and all activities continued till the fourth week.
CONCLUSIONS: CGF has the potential to effectively enhance orthodontic tooth movement without adverse clinical or histological effects.
摘要：
背景：本研究旨在评估浓缩生长因子（CGF）注射如何影响兔正畸牙齿移动的速度。
方法：这项实验研究采用了裂口构型。在上颌第一磨牙正畸化之前，在一个随机分配的象限中，在上颌第一磨牙的颊侧和腭侧使用粘膜下注射制备并施用CGF。使用相反的象限作为对照。该研究检查了四个时间点：1、2、3和4周。使用数字卡尺在每个随访点进行牙齿移动的测量。兔子被安乐死，和他们的上颌段，特别是上颌第一磨牙，进行组织学研究，以确定拉伸和压缩侧发生的任何变化。
结果：在实验侧观察到明显的牙齿移动，第三,随访第4周（p≤0.05）。组织学上,在压缩方面，CGF组从第一周开始出现骨吸收和牙周膜活性反应,并持续到接下来的三周.此外，在紧张的一面，CGF组描述了从第一周开始的骨水泥和成骨细胞活动，然后从第二周开始的成纤维细胞活动，所有活动一直持续到第四周。
结论：CGF具有有效增强正畸牙齿移动的潜力，而不会产生不良的临床或组织学影响。
方法：这项实验研究采用了裂口构型。在上颌第一磨牙正畸化之前，在一个随机分配的象限中，在上颌第一磨牙的颊侧和腭侧使用粘膜下注射制备并施用CGF。使用相反的象限作为对照。该研究检查了四个时间点：1、2、3和4周。使用数字卡尺在每个随访点进行牙齿移动的测量。兔子被安乐死，和他们的上颌段，特别是上颌第一磨牙，进行组织学研究，以确定拉伸和压缩侧发生的任何变化。
结果：在实验侧观察到明显的牙齿移动，第三,随访第4周（p≤0.05）。组织学上,在压缩方面，CGF组从第一周开始出现骨吸收和牙周膜活性反应,并持续到接下来的三周.此外，在紧张的一面，CGF组描述了从第一周开始的骨水泥和成骨细胞活动，然后从第二周开始的成纤维细胞活动，所有活动一直持续到第四周。
结论：CGF具有有效增强正畸牙齿移动的潜力，而不会产生不良的临床或组织学影响。
