PDF(Pubmed)
Abstract：
The human subcortex plays a pivotal role in cognition and is widely implicated in the pathophysiology of many psychiatric disorders. However, the heritability of functional gradients based on subcortico-cortical functional connectivity remains elusive. Here, leveraging twin functional MRI (fMRI) data from both the Human Connectome Project (n = 1023) and the Adolescent Brain Cognitive Development study (n = 936) datasets, we construct large-scale subcortical functional gradients and delineate an increased principal functional gradient pattern from unimodal sensory/motor networks to transmodal association networks. We observed that this principal functional gradient is heritable, and the strength of heritability exhibits a heterogeneous pattern along a hierarchical unimodal-transmodal axis in subcortex for both young adults and children. Furthermore, employing a machine learning framework, we show that this heterogeneous pattern of the principal functional gradient in subcortex can accurately discern the relationship between monozygotic twin pairs and dizygotic twin pairs with an accuracy of 76.2% (P < 0.001). The heritability of functional gradients is associated with the anatomical myelin proxied by MRI-derived T1-weighted/T2-weighted (T1w/T2w) ratio mapping in subcortex. This study provides new insights into the biological basis of subcortical functional hierarchy by revealing the structural and genetic properties of the subcortical functional gradients.
摘要：
人类皮质下在认知中起着关键作用，并广泛涉及许多精神疾病的病理生理学。然而,基于皮质下-皮质功能连接的功能梯度的遗传力仍然难以捉摸。这里,利用来自人类连接体项目（n=1023）和青少年大脑认知发育研究（n=936）数据集的双功能MRI（fMRI）数据，我们构建了大规模的皮质下功能梯度,并描绘了从单峰感觉/运动网络到跨模态关联网络的增加的主要功能梯度模式.我们观察到这个主要的功能梯度是可遗传的，对于年轻人和儿童，遗传力的强度沿皮层下的分层单峰-跨模态轴表现出异质模式。此外，采用机器学习框架，我们表明，皮质下主要功能梯度的这种异质性模式可以准确地辨别单卵双胞胎对和二卵双胞胎对之间的关系，准确率为76.2%(P<0.001)。功能梯度的遗传度与皮质下MRI衍生的T1加权/T2加权（T1w/T2w）比率映射所产生的解剖学髓鞘有关。这项研究通过揭示皮质下功能梯度的结构和遗传特性，为皮质下功能层次的生物学基础提供了新的见解。
