肿瘤抑制因子的缺失促进炎性肿瘤微环境并增强 LAG3 + T 细胞介导的免疫抑制。
Mesh : Tumor Microenvironment / immunology Animals Lymphocyte Activation Gene 3 Protein Mice Female Humans Triple Negative Breast Neoplasms / immunology pathology genetics Immune Checkpoint Inhibitors / pharmacology therapeutic use Tuberous Sclerosis Complex 1 Protein / genetics metabolism B7-H1 Antigen / metabolism genetics Neurofibromin 1 / genetics metabolism Cell Line, Tumor CD8-Positive T-Lymphocytes / immunology Inflammation / immunology CD4-Positive T-Lymphocytes / immunology Gene Expression Regulation, Neoplastic CRISPR-Cas Systems
来 源:
DOI:10.1038/s41467-024-50262-8
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